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10.1038/nm.4035 http://scihub22266oqcxt.onion/10.1038/nm.4035 C4872630!4872630 !26779814     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26779814 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2016 ; 22 (2 ): 154-62 Nephropedia Template TP {{tp|p=26779814 |t=2016. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis |pdf=|usr=}}{{26779814 }} gab.com Text Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26779814 #FOAvip Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we study how a hematopoietic-vascular niche regulates alveolar repair and lung fibrosis. Using intratracheal injection of bleomycin or hydrochloric acid in mice, we show that repetitive lung injury activates pulmonary capillary endothelial cells (PCECs) and perivascular macrophages, impeding alveolar repair and promoting fibrosis. Whereas the chemokine receptor CXCR7, expressed on PCECs, acts to prevent epithelial damage and ameliorate fibrosis after a single round of treatment with bleomycin or hydrochloric acid, repeated injury leads to suppression of CXCR7 expression and recruitment of vascular endothelial growth factor receptor 1 (VEGFR1)-expressing perivascular macrophages. This recruitment stimulates Wnt/?-catenin-dependent persistent upregulation of the Notch ligand Jagged1 (encoded by Jag1) in PCECs, which in turn stimulates exuberant Notch signaling in perivascular fibroblasts and enhances fibrosis. Administration of a CXCR7 agonist or PCEC-targeted Jag1 shRNA after lung injury promotes alveolar repair and reduces fibrosis. Thus, targeting of a maladapted hematopoietic-vascular niche, in which macrophages, PCECs and perivascular fibroblasts interact, may help to develop therapy to spur lung regeneration and alleviate fibrosis. Twit Text FOAVip Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26779814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26779814 #FOAvip English Wikipedia <ref>{{Cite pmid|26779814 }}</ref> Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis #MMPMID26779814 Cao Z ; Lis R ; Ginsberg M ; Chavez D ; Shido K ; Rabbany SY ; Fong GH ; Sakmar TP ; Rafii S ; Ding BS Nat Med 2016[Feb]; 22 (2 ): 154-62 PMID26779814 show ga Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we study how a hematopoietic-vascular niche regulates alveolar repair and lung fibrosis. Using intratracheal injection of bleomycin or hydrochloric acid in mice, we show that repetitive lung injury activates pulmonary capillary endothelial cells (PCECs) and perivascular macrophages, impeding alveolar repair and promoting fibrosis. Whereas the chemokine receptor CXCR7, expressed on PCECs, acts to prevent epithelial damage and ameliorate fibrosis after a single round of treatment with bleomycin or hydrochloric acid, repeated injury leads to suppression of CXCR7 expression and recruitment of vascular endothelial growth factor receptor 1 (VEGFR1)-expressing perivascular macrophages. This recruitment stimulates Wnt/?-catenin-dependent persistent upregulation of the Notch ligand Jagged1 (encoded by Jag1) in PCECs, which in turn stimulates exuberant Notch signaling in perivascular fibroblasts and enhances fibrosis. Administration of a CXCR7 agonist or PCEC-targeted Jag1 shRNA after lung injury promotes alveolar repair and reduces fibrosis. Thus, targeting of a maladapted hematopoietic-vascular niche, in which macrophages, PCECs and perivascular fibroblasts interact, may help to develop therapy to spur lung regeneration and alleviate fibrosis. |Animals [MESH] |Antibiotics, Antineoplastic/toxicity [MESH] |Bleomycin/toxicity [MESH] |Calcium-Binding Proteins/antagonists & inhibitors/*metabolism [MESH] |Capillaries/drug effects/*metabolism [MESH] |Endothelial Cells/drug effects/*metabolism/physiology [MESH] |Fibroblasts/drug effects/*metabolism [MESH] |Fibrosis [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Hydrochloric Acid/toxicity [MESH] |Intercellular Signaling Peptides and Proteins/*metabolism [MESH] |Jagged-1 Protein [MESH] |Lung Injury/*metabolism [MESH] |Lung/drug effects/*metabolism/pathology/physiology [MESH] |Macrophages/drug effects/metabolism [MESH] |Membrane Proteins/antagonists & inhibitors/*metabolism [MESH] |Mice [MESH] |Oligopeptides/pharmacology [MESH] |Pulmonary Artery/drug effects/metabolism [MESH] |Pulmonary Circulation/drug effects/physiology [MESH] |Pulmonary Fibrosis/*metabolism [MESH] |RNA, Small Interfering/pharmacology [MESH] |Receptors, CXCR/agonists/*metabolism [MESH] |Receptors, Notch/metabolism [MESH] |Regeneration/drug effects/*physiology [MESH] |Serrate-Jagged Proteins [MESH] |Smad3 Protein/drug effects/metabolism [MESH] |Vascular Endothelial Growth Factor Receptor-1/metabolism [MESH]Targeting of the pulmonary capillary vascular niche promotes lung alve(epmc).pdf DeepDyve Pubget Overpricing