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2005 ; 83
(2
): 349-54
Nephropedia Template TP
gab.com Text
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English Wikipedia
Association between Beckwith-Wiedemann syndrome and assisted reproductive
technology: a case series of 19 patients
#MMPMID15705373
Chang AS
; Moley KH
; Wangler M
; Feinberg AP
; Debaun MR
Fertil Steril
2005[Feb]; 83
(2
): 349-54
PMID15705373
show ga
OBJECTIVE: An association between assisted reproductive technique (ART) and
specific imprinting mutations, such as Beckwith-Wiedemann syndrome (BWS), has
recently been documented. Based on experiments in farm animals that demonstrated
an association between alterations in culture media during ART and large
offspring syndrome, we hypothesized that the culture media could be implicated as
a common factor among the children with BWS conceived after ART. DESIGN:
Retrospective case series. SETTING: Registry from Academic Medical Center.
PATIENT(S): Nineteen children born after ART were identified within the registry.
MAIN OUTCOME MEASURE(S): Demographics of patients, type of ART, culture media,
IVF parameters. RESULT(S): Twelve of the 19 medical records from the reproductive
endocrine centers were successfully obtained. Ten of 12 mothers of children with
BWS had IVF, but no single, consistent culture media was used in this group. Half
of the patients underwent IVF with intracytoplasmic sperm injection (ICSI; n =
5), whereas the other half had routine IVF. One child was conceived through
clomiphene citrate (CC) stimulation and artificial insemination, whereas another
patient conceived through gonadotropin stimulation with intrauterine insemination
(IUI). The gonadotropin dosage and quantity of embryos transferred also varied
significantly. The only consistent finding was that all 12 women received some
type of ovarian stimulation medication. CONCLUSION(S): Large epidemiologic
studies are needed to further study the association between BWS and ART.