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10.1038/srep26226 http://scihub22266oqcxt.onion/10.1038/srep26226 C4872162!4872162 !27194451     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27194451 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26226 Nephropedia Template TP {{tp|p=27194451 |t=2016. Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A |pdf=|usr=}}{{27194451 }} gab.com Text Cell-cell contact and matrix adhesion promote SMA expression during TGF 1-induced epithelial-myofibroblast transition via Notch and MRTF-A JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27194451 #FOAvip During epithelial-mesenchymal transition (EMT) epithelial cells lose cell-cell adhesion, exhibit morphological changes, and upregulate the expression of cytoskeletal proteins. Previous studies have demonstrated that complete disruption of cell-cell contact can promote transforming growth factor (TGF)-?1-induced EMT and the expression of the myofibroblast marker alpha smooth muscle actin (?SMA). Furthermore, increased cell spreading mediates TGF?1-induced ?SMA expression during EMT. Here, we sought to examine how the presence of partial cell-cell contacts impacts EMT. A microfabrication approach was employed to decouple the effects of cell-cell contact and cell-matrix adhesion in TGF?1-induced EMT. When cell spreading is controlled, the presence of partial cell-cell contacts enhances expression of ?SMA. Moreover, cell spreading and intercellular contacts together control the subcellular localization of activated Notch1 and myocardin related transcription factor (MRTF)-A. Knockdown of Notch1 or MRTF-A as well as pharmacological inhibition of these pathways abates the cell-cell contact mediated expression of ?SMA. These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGF?1-induced EMT. Twit Text FOAVip Cell-cell contact and matrix adhesion promote SMA expression during TGF 1-induced epithelial-myofibroblast transition via Notch and MRTF-A ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27194451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27194451 #FOAvip English Wikipedia <ref>{{Cite pmid|27194451 }}</ref> Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A #MMPMID27194451 O'Connor JW ; Mistry K ; Detweiler D ; Wang C ; Gomez EW Sci Rep 2016[May]; 6 (ä): 26226 PMID27194451 show ga During epithelial-mesenchymal transition (EMT) epithelial cells lose cell-cell adhesion, exhibit morphological changes, and upregulate the expression of cytoskeletal proteins. Previous studies have demonstrated that complete disruption of cell-cell contact can promote transforming growth factor (TGF)-?1-induced EMT and the expression of the myofibroblast marker alpha smooth muscle actin (?SMA). Furthermore, increased cell spreading mediates TGF?1-induced ?SMA expression during EMT. Here, we sought to examine how the presence of partial cell-cell contacts impacts EMT. A microfabrication approach was employed to decouple the effects of cell-cell contact and cell-matrix adhesion in TGF?1-induced EMT. When cell spreading is controlled, the presence of partial cell-cell contacts enhances expression of ?SMA. Moreover, cell spreading and intercellular contacts together control the subcellular localization of activated Notch1 and myocardin related transcription factor (MRTF)-A. Knockdown of Notch1 or MRTF-A as well as pharmacological inhibition of these pathways abates the cell-cell contact mediated expression of ?SMA. These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGF?1-induced EMT. |*Cell Adhesion [MESH] |*Epithelial-Mesenchymal Transition [MESH] |Actins/*metabolism [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Dogs [MESH] |Epithelial Cells/*physiology [MESH] |Extracellular Matrix/*metabolism [MESH] |Gene Knockdown Techniques [MESH] |Mice [MESH] |Myofibroblasts/*physiology [MESH] |Receptor, Notch1/metabolism [MESH] |Trans-Activators/metabolism [MESH]Cell-cell contact and matrix adhesion promote ?SMA expression during (epmc).pdf DeepDyve Pubget Overpricing