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10.1038/srep26070

http://scihub22266oqcxt.onion/10.1038/srep26070
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C4872127!4872127 !27194381
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suck abstract from ncbi


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pmid27194381
      Sci+Rep 2016 ; 6 (ä): 26070
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  • Efficacy of Fluidized Bed Bioartificial Liver in Treating Fulminant Hepatic Failure in Pigs: A Metabolomics Study #MMPMID27194381
  • Zhou P ; Shao L ; Zhao L ; Lv G ; Pan X ; Zhang A ; Li J ; Zhou N ; Chen D ; Li L
  • Sci Rep 2016[May]; 6 (ä): 26070 PMID27194381 show ga
  • Bioartificial livers may act as a promising therapy for fulminant hepatic failure (FHF) with better accessibility and less injury compared to orthotopic liver transplantation. This study aims to evaluate the efficacy and safety of a fluidized bed bioartificial liver (FBBAL) and to explore its therapeutic mechanisms based on metabolomics. FHF was induced by D-galactosamine. Eighteen hours later, pigs were treated with an FBBAL containing encapsulated primary porcine hepatocytes (B group), with a sham FBBAL (containing cell-free capsules, S group) or with only intensive care (C group) for 6?h. Serum samples were assayed using ultra-performance liquid chromatography-mass spectrometry. The difference in survival time (51.6?±?7.9?h vs. 49.3?±?6.6?h) and serum metabolome was negligible between the S and C groups, whereas FBBAL treatment significantly prolonged survival time (70.4?±?11.5h, P?
  • |*Liver, Artificial [MESH]
  • |*Metabolomics [MESH]
  • |Animals [MESH]
  • |Cell Transplantation/adverse effects/*methods [MESH]
  • |Cells, Immobilized/metabolism [MESH]
  • |Chromatography, Liquid [MESH]
  • |Disease Models, Animal [MESH]
  • |Liver Failure, Acute/chemically induced/*therapy [MESH]
  • |Mass Spectrometry [MESH]
  • |Serum/chemistry [MESH]
  • |Survival Analysis [MESH]
  • |Swine [MESH]


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