Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27194381
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2016 ; 6
(ä): 26070
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Efficacy of Fluidized Bed Bioartificial Liver in Treating Fulminant Hepatic
Failure in Pigs: A Metabolomics Study
#MMPMID27194381
Zhou P
; Shao L
; Zhao L
; Lv G
; Pan X
; Zhang A
; Li J
; Zhou N
; Chen D
; Li L
Sci Rep
2016[May]; 6
(ä): 26070
PMID27194381
show ga
Bioartificial livers may act as a promising therapy for fulminant hepatic failure
(FHF) with better accessibility and less injury compared to orthotopic liver
transplantation. This study aims to evaluate the efficacy and safety of a
fluidized bed bioartificial liver (FBBAL) and to explore its therapeutic
mechanisms based on metabolomics. FHF was induced by D-galactosamine. Eighteen
hours later, pigs were treated with an FBBAL containing encapsulated primary
porcine hepatocytes (B group), with a sham FBBAL (containing cell-free capsules,
S group) or with only intensive care (C group) for 6?h. Serum samples were
assayed using ultra-performance liquid chromatography-mass spectrometry. The
difference in survival time (51.6?±?7.9?h vs. 49.3?±?6.6?h) and serum metabolome
was negligible between the S and C groups, whereas FBBAL treatment significantly
prolonged survival time (70.4?±?11.5h, P?0.01) and perturbed the serum
metabolome, resulting in a marked decrease in phosphatidylcholines,
lysophosphatidylcholines, sphingomyelinase, and fatty acids and an increase in
conjugated bile acids. The FBBAL exhibits some liver functions and may exert its
therapeutic effect by altering the serum metabolome of FHF pigs. Moreover,
alginate-chitosan capsules have less influence on serum metabolites.
Nevertheless, the alterations were not universally beneficial, revealing that
much should be done to improve the FBBAL.