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10.1093/nar/gkw043 http://scihub22266oqcxt.onion/10.1093/nar/gkw043 C4872079!4872079!26825463     free     free     free       Nucleic+Acids+Res 2016 ; 44 (9): e82 Nephropedia Template TP {{tp|p=26825463|t=2016. A structural view of microRNA?target recognition |pdf=|usr=}}{{26825463}} gab.com Text A structural view of microRNA target recognition JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26825463 #FOAvip It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity. We hypothesize that the correct identification of the pairing should take into account the effect of the Argonaute protein (AGO), an essential catalyst of the recognition process. Therefore, we developed a strategy named MiREN for building and scoring three-dimensional models of the ternary complex formed by AGO, a miRNA and 22 nt of a target mRNA that putatively interacts with it. We show here that MiREN can be used to assess the likelihood that an RNA molecule is the target of a given miRNA and that this approach is more accurate than other existing methods, usually based on sequence or sequence-related features. Our results also suggest that AGO plays a relevant role in the selection of the miRNA targets. Our method can represent an additional step for refining predictions made by faster but less accurate classical methods for the identification of miRNA targets. Twit Text FOAVip A structural view of microRNA target recognition ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26825463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26825463 #FOAvip English Wikipedia <ref>{{Cite pmid|26825463}}</ref> A structural view of microRNA?target recognition #MMPMID26825463 Leoni G; Tramontano A Nucleic Acids Res 2016[May]; 44 (9): e82 PMID26825463show ga It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity. We hypothesize that the correct identification of the pairing should take into account the effect of the Argonaute protein (AGO), an essential catalyst of the recognition process. Therefore, we developed a strategy named MiREN for building and scoring three-dimensional models of the ternary complex formed by AGO, a miRNA and 22 nt of a target mRNA that putatively interacts with it. We show here that MiREN can be used to assess the likelihood that an RNA molecule is the target of a given miRNA and that this approach is more accurate than other existing methods, usually based on sequence or sequence-related features. Our results also suggest that AGO plays a relevant role in the selection of the miRNA targets. Our method can represent an additional step for refining predictions made by faster but less accurate classical methods for the identification of miRNA targets. äA structural view of microRNA?target recognition (epmc).pdf DeepDyve Pubget Overpricing