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10.1016/j.immuni.2016.02.009

http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.02.009
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C4871732!4871732!27130899
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suck abstract from ncbi


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pmid27130899      Immunity 2016 ; 44 (5): 1102-13
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  • Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage #MMPMID27130899
  • Malchow S; Leventhal DS; Lee V; Nishi S; Socci ND; Savage PA
  • Immunity 2016[May]; 44 (5): 1102-13 PMID27130899show ga
  • The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by Autoimmune Regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack. Aire-dependent processes are thought to promote both clonal deletion and the development of Foxp3+ regulatory T (Treg) cells, suggesting that autoimmunity associated with Aire deficiency results from two failed tolerance mechanisms. Here, examination of autoimmune lesions in Aire?/? mice revealed an unexpected third possibility. We found that the predominant conventional T cell clonotypes infiltrating target lesions express antigen receptors that were preferentially expressed by Foxp3+ Treg cells in Aire+/+ mice. Thus, Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage; dysregulation of this process results in the diversion of Treg cell-biased clonotypes into pathogenic conventional T cells.
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