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10.1016/j.immuni.2016.02.009 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.02.009 C4871732!4871732 !27130899     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27130899 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2016 ; 44 (5 ): 1102-13 Nephropedia Template TP {{tp|p=27130899 |t=2016. Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage |pdf=|usr=}}{{27130899 }} gab.com Text Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27130899 #FOAvip The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack. Aire-dependent processes are thought to promote both clonal deletion and the development of Foxp3(+) regulatory T (Treg) cells, suggesting that autoimmunity associated with Aire deficiency results from two failed tolerance mechanisms. Here, examination of autoimmune lesions in Aire(-/-) mice revealed an unexpected third possibility. We found that the predominant conventional T cell clonotypes infiltrating target lesions express antigen receptors that were preferentially expressed by Foxp3(+) Treg cells in Aire(+/+) mice. Thus, Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage; dysregulation of this process results in the diversion of Treg cell-biased clonotypes into pathogenic conventional T cells. Twit Text FOAVip Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27130899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27130899 #FOAvip English Wikipedia <ref>{{Cite pmid|27130899 }}</ref> Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage #MMPMID27130899 Malchow S ; Leventhal DS ; Lee V ; Nishi S ; Socci ND ; Savage PA Immunity 2016[May]; 44 (5 ): 1102-13 PMID27130899 show ga The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack. Aire-dependent processes are thought to promote both clonal deletion and the development of Foxp3(+) regulatory T (Treg) cells, suggesting that autoimmunity associated with Aire deficiency results from two failed tolerance mechanisms. Here, examination of autoimmune lesions in Aire(-/-) mice revealed an unexpected third possibility. We found that the predominant conventional T cell clonotypes infiltrating target lesions express antigen receptors that were preferentially expressed by Foxp3(+) Treg cells in Aire(+/+) mice. Thus, Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage; dysregulation of this process results in the diversion of Treg cell-biased clonotypes into pathogenic conventional T cells. |*Autoimmunity/genetics [MESH] |*Immune Tolerance/genetics [MESH] |AIRE Protein [MESH] |Animals [MESH] |Autoantigens/immunology [MESH] |Cell Differentiation [MESH] |Cell Lineage [MESH] |Clonal Deletion [MESH] |Clonal Selection, Antigen-Mediated [MESH] |Clone Cells [MESH] |Forkhead Transcription Factors/genetics/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Prostate/*immunology [MESH] |T-Cell Antigen Receptor Specificity [MESH] |T-Lymphocyte Subsets/*physiology [MESH] |T-Lymphocytes, Regulatory/*physiology [MESH] |Thymus Gland/*immunology [MESH]Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into (epmc).pdf DeepDyve Pubget Overpricing