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10.1371/journal.pone.0155486 http://scihub22266oqcxt.onion/10.1371/journal.pone.0155486 C4871364!4871364 !27186977     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27186977 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (5 ): e0155486 Nephropedia Template TP {{tp|p=27186977 |t=2016. TGF-? Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis |pdf=|usr=}}{{27186977 }} gab.com Text TGF- Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27186977 #FOAvip Rotator cuff tears represent a large burden of muscle-tendon injuries in our aging population. While small tears can be repaired surgically with good outcomes, critical size tears are marked by muscle atrophy, fibrosis, and fatty infiltration, which can lead to failed repair, frequent re-injury, and chronic disability. Previous animal studies have indicated that Transforming Growth Factor-? (TGF-?) signaling may play an important role in the development of these muscle pathologies after injury. Here, we demonstrated that inhibition of TGF-?1 signaling with the small molecule inhibitor SB431542 in a mouse model of massive rotator cuff tear results in decreased fibrosis, fatty infiltration, and muscle weight loss. These observed phenotypic changes were accompanied by decreased fibrotic, adipogenic, and atrophy-related gene expression in the injured muscle of mice treated with SB431542. We further demonstrated that treatment with SB431542 reduces the number of fibro/adipogenic progenitor (FAP) cells-an important cellular origin of rotator cuff muscle fibrosis and fatty infiltration, in injured muscle by promoting apoptosis of FAPs. Together, these data indicate that the TGF-? pathway is a critical regulator of the degenerative muscle changes seen after massive rotator cuff tears. TGF-? promotes rotator cuff muscle fibrosis and fatty infiltration by preventing FAP apoptosis. TGF-? regulated FAP apoptosis may serve as an important target pathway in the future development of novel therapeutics to improve muscle outcomes following rotator cuff tear. Twit Text FOAVip TGF- Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27186977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27186977 #FOAvip English Wikipedia <ref>{{Cite pmid|27186977 }}</ref> TGF-? Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis #MMPMID27186977 Davies MR ; Liu X ; Lee L ; Laron D ; Ning AY ; Kim HT ; Feeley BT PLoS One 2016[]; 11 (5 ): e0155486 PMID27186977 show ga Rotator cuff tears represent a large burden of muscle-tendon injuries in our aging population. While small tears can be repaired surgically with good outcomes, critical size tears are marked by muscle atrophy, fibrosis, and fatty infiltration, which can lead to failed repair, frequent re-injury, and chronic disability. Previous animal studies have indicated that Transforming Growth Factor-? (TGF-?) signaling may play an important role in the development of these muscle pathologies after injury. Here, we demonstrated that inhibition of TGF-?1 signaling with the small molecule inhibitor SB431542 in a mouse model of massive rotator cuff tear results in decreased fibrosis, fatty infiltration, and muscle weight loss. These observed phenotypic changes were accompanied by decreased fibrotic, adipogenic, and atrophy-related gene expression in the injured muscle of mice treated with SB431542. We further demonstrated that treatment with SB431542 reduces the number of fibro/adipogenic progenitor (FAP) cells-an important cellular origin of rotator cuff muscle fibrosis and fatty infiltration, in injured muscle by promoting apoptosis of FAPs. Together, these data indicate that the TGF-? pathway is a critical regulator of the degenerative muscle changes seen after massive rotator cuff tears. TGF-? promotes rotator cuff muscle fibrosis and fatty infiltration by preventing FAP apoptosis. TGF-? regulated FAP apoptosis may serve as an important target pathway in the future development of novel therapeutics to improve muscle outcomes following rotator cuff tear. |Adipose Tissue/drug effects/*pathology [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |Benzamides/*pharmacology [MESH] |Dioxoles/*pharmacology [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Fibrosis [MESH] |Gene Expression Regulation/drug effects [MESH] |Mice [MESH] |Muscular Atrophy/drug therapy [MESH] |Rotator Cuff Injuries/genetics/metabolism/*pathology [MESH] |Rotator Cuff/drug effects/metabolism/*pathology [MESH] |Signal Transduction/drug effects [MESH] |Stem Cells/*cytology/*drug effects [MESH]TGF-? Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fi(epmc).pdf DeepDyve Pubget Overpricing