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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Immunol+Rev 2008 ; 225 (ä): 244-55 Nephropedia Template TP
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Humoral and Cell-Mediated Immunity to the Intracellular Pathogen Francisella tularensis #MMPMID18837786
Kirimanjeswara GS; Olmos S; Bakshi CS; Metzger DW
Immunol Rev 2008[Oct]; 225 (ä): 244-55 PMID18837786show ga
Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the US and several European countries. The correlates of protective immunity against this intracellular bacterium are not known and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.