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10.1007/978-3-319-22380-3_5 http://scihub22266oqcxt.onion/10.1007/978-3-319-22380-3_5 C4871243!4871243!26662987     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Exp+Med+Biol 2015 ; 887 (ä): 79-100 Nephropedia Template TP {{tp|p=26662987|t=2015. Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis |pdf=|usr=}}{{26662987}} gab.com Text Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=26662987 #FOAvip MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional regulators of gene expression being involved in the fine control of a plethora of physiological and pathological processes. Besides their well-established crucial roles in the regulation of cell cycle, embryogenesis or tumorigenesis, these tiny molecules have also been shown to participate in the regulation of lipid metabolism. In particular, miRs orchestrate cholesterol and fatty acids synthesis, transport, and degradation and low-density and high-density lipoprotein (LDL and HDL) formation. It is thus not surprising that they have also been reported to affect the development and progression of several lipid metabolism-related disorders including liver steatosis and atherosclerosis. Mounting evidence suggests that miRs might represent important ?posttranscriptional hubs? of lipid metabolism, which means that one miR usually targets 3?-untranslated regions of various mRNAs that are involved in different steps of one precise metabolic/signaling pathway, e.g., one miR targets mRNAs of enzymes important for cholesterol synthesis, degradation, and transport. Therefore, changes in the levels of one key miR affect various steps of one pathway, which is thereby promoted or inhibited. This makes miRs potent future diagnostic and even therapeutic tools for personalized medicine. Within this chapter, the most prominent microRNAs involved in lipid metabolism, e.g., miR-27a/b, miR-33/33*, miR-122, miR-144, or miR-223, and their intracellular and extracellular functions will be extensively discussed, in particular focusing on their mechanistic role in the pathophysiology of atherosclerosis. Special emphasis will be given on miR-122, the first microRNA currently in clinical trials for the treatment of hepatitis C and on miR-223, the most abundant miR in lipoprotein particles. Twit Text FOAVip Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=26662987 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26662987 #FOAvip English Wikipedia <ref>{{Cite pmid|26662987}}</ref> Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis #MMPMID26662987 Novák J; Olejní?ková V; Tká?ová N; Santulli G Adv Exp Med Biol 2015[]; 887 (ä): 79-100 PMID26662987show ga MicroRNAs (miRNAs, miRs) represent a group of powerful and versatile posttranscriptional regulators of gene expression being involved in the fine control of a plethora of physiological and pathological processes. Besides their well-established crucial roles in the regulation of cell cycle, embryogenesis or tumorigenesis, these tiny molecules have also been shown to participate in the regulation of lipid metabolism. In particular, miRs orchestrate cholesterol and fatty acids synthesis, transport, and degradation and low-density and high-density lipoprotein (LDL and HDL) formation. It is thus not surprising that they have also been reported to affect the development and progression of several lipid metabolism-related disorders including liver steatosis and atherosclerosis. Mounting evidence suggests that miRs might represent important ?posttranscriptional hubs? of lipid metabolism, which means that one miR usually targets 3?-untranslated regions of various mRNAs that are involved in different steps of one precise metabolic/signaling pathway, e.g., one miR targets mRNAs of enzymes important for cholesterol synthesis, degradation, and transport. Therefore, changes in the levels of one key miR affect various steps of one pathway, which is thereby promoted or inhibited. This makes miRs potent future diagnostic and even therapeutic tools for personalized medicine. Within this chapter, the most prominent microRNAs involved in lipid metabolism, e.g., miR-27a/b, miR-33/33*, miR-122, miR-144, or miR-223, and their intracellular and extracellular functions will be extensively discussed, in particular focusing on their mechanistic role in the pathophysiology of atherosclerosis. Special emphasis will be given on miR-122, the first microRNA currently in clinical trials for the treatment of hepatitis C and on miR-223, the most abundant miR in lipoprotein particles. äMechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atheros(epmc).pdf DeepDyve Pubget Overpricing