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10.1177/0883073815627882 http://scihub22266oqcxt.onion/10.1177/0883073815627882 C4871174!4871174 !26823478     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26823478 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Child+Neurol 2016 ; 31 (7 ): 899-906 Nephropedia Template TP {{tp|p=26823478 |t=2016. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience |pdf=|usr=}}{{26823478 }} gab.com Text Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience JO: J Child Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26823478 #FOAvip Nusinersen (ISIS-SMNRx or ISIS 396443) is an antisense oligonucleotide drug administered intrathecally to treat spinal muscular atrophy. We summarize lumbar puncture experience in children with spinal muscular atrophy during a phase 1 open-label study of nusinersen and its extension. During the studies, 73 lumbar punctures were performed in 28 patients 2 to 14 years of age with type 2/3 spinal muscular atrophy. No complications occurred in 50 (68%) lumbar punctures; in 23 (32%) procedures, adverse events were attributed to lumbar puncture. Most common adverse events were headache (n = 9), back pain (n = 9), and post-lumbar puncture syndrome (n = 8). In a subgroup analysis, adverse events were more frequent in older children, children with type 3 spinal muscular atrophy, and with a 21- or 22-gauge needle compared to a 24-gauge needle or smaller. Lumbar punctures were successfully performed in children with spinal muscular atrophy; lumbar puncture-related adverse event frequency was similar to that previously reported in children. Twit Text FOAVip Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience ????J Child Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26823478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26823478 #FOAvip English Wikipedia <ref>{{Cite pmid|26823478 }}</ref> Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience #MMPMID26823478 Haché M ; Swoboda KJ ; Sethna N ; Farrow-Gillespie A ; Khandji A ; Xia S ; Bishop KM J Child Neurol 2016[Jun]; 31 (7 ): 899-906 PMID26823478 show ga Nusinersen (ISIS-SMNRx or ISIS 396443) is an antisense oligonucleotide drug administered intrathecally to treat spinal muscular atrophy. We summarize lumbar puncture experience in children with spinal muscular atrophy during a phase 1 open-label study of nusinersen and its extension. During the studies, 73 lumbar punctures were performed in 28 patients 2 to 14 years of age with type 2/3 spinal muscular atrophy. No complications occurred in 50 (68%) lumbar punctures; in 23 (32%) procedures, adverse events were attributed to lumbar puncture. Most common adverse events were headache (n = 9), back pain (n = 9), and post-lumbar puncture syndrome (n = 8). In a subgroup analysis, adverse events were more frequent in older children, children with type 3 spinal muscular atrophy, and with a 21- or 22-gauge needle compared to a 24-gauge needle or smaller. Lumbar punctures were successfully performed in children with spinal muscular atrophy; lumbar puncture-related adverse event frequency was similar to that previously reported in children. |Adolescent [MESH] |Child [MESH] |Child, Preschool [MESH] |Female [MESH] |Humans [MESH] |Injections, Spinal/adverse effects [MESH] |Male [MESH] |Muscular Atrophy, Spinal/*drug therapy [MESH] |Neuromuscular Agents/*administration & dosage/adverse effects [MESH] |Oligonucleotides/*administration & dosage/adverse effects [MESH]Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusin(epmc).pdf DeepDyve Pubget Overpricing