Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/jbmr.1617 http://scihub22266oqcxt.onion/10.1002/jbmr.1617 C4871126!4871126!22549910     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Bone+Miner+Res 2012 ; 27 (6): 1231-9 Nephropedia Template TP {{tp|p=22549910|t=2012. Twenty-five Years of PTHrP Progress from Cancer Hormone to Multifunctional Cytokine |pdf=|usr=}}{{22549910}} gab.com Text Twenty-five Years of PTHrP Progress from Cancer Hormone to Multifunctional Cytokine JO: J Bone Miner Res http://www.kidney.de/pget.php?&tw=1&pmid=22549910 #FOAvip Twenty-five years ago a ?new? protein was identified from cancers that caused hypercalcemia. It was credited for its ability to mimic parathyroid hormone, and hence was termed parathyroid hormone-related protein (PTHrP). Today it is recognized for its widespread distribution, its endocrine, paracrine, and intracrine modes of action driving numerous physiologic and pathologic conditions with a central role in organogenesis. The multiple biological activities within a complex molecule with paracrine modulation of adjacent target cells present boundless possibilities. The protein structure of PTHrP has been traced, dissected and deleted comprehensively and conditionally, yet numerous questions lurk in its past that will carry into the future. Issues of the variable segments of the protein including the enigmatic nuclear localization sequence are only recently being clarified. Aspects of PTHrP production and action in the menacing condition of cancer are emerging as dichotomies that may represent intended temporal actions of PTHrP. Relative to PTH, the hormone regulating calcium homeostasis, PTHrP ?controls the show? locally at the PTH/PTHrP receptor throughout the body. Great strides have been made in our understanding of PTHrP actions, yet years of exciting investigation and discovery are imminent. Twit Text FOAVip Twenty-five Years of PTHrP Progress from Cancer Hormone to Multifunctional Cytokine ????J Bone Miner Res http://www.kidney.de/pget.php?&tw=1&pmid=22549910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22549910 #FOAvip English Wikipedia <ref>{{Cite pmid|22549910}}</ref> Twenty-five Years of PTHrP Progress from Cancer Hormone to Multifunctional Cytokine #MMPMID22549910 McCauley LK; Martin TJ J Bone Miner Res 2012[Jun]; 27 (6): 1231-9 PMID22549910show ga Twenty-five years ago a ?new? protein was identified from cancers that caused hypercalcemia. It was credited for its ability to mimic parathyroid hormone, and hence was termed parathyroid hormone-related protein (PTHrP). Today it is recognized for its widespread distribution, its endocrine, paracrine, and intracrine modes of action driving numerous physiologic and pathologic conditions with a central role in organogenesis. The multiple biological activities within a complex molecule with paracrine modulation of adjacent target cells present boundless possibilities. The protein structure of PTHrP has been traced, dissected and deleted comprehensively and conditionally, yet numerous questions lurk in its past that will carry into the future. Issues of the variable segments of the protein including the enigmatic nuclear localization sequence are only recently being clarified. Aspects of PTHrP production and action in the menacing condition of cancer are emerging as dichotomies that may represent intended temporal actions of PTHrP. Relative to PTH, the hormone regulating calcium homeostasis, PTHrP ?controls the show? locally at the PTH/PTHrP receptor throughout the body. Great strides have been made in our understanding of PTHrP actions, yet years of exciting investigation and discovery are imminent. äTwenty-five Years of PTHrP Progress from Cancer Hormone to Multifuncti(epmc).pdf DeepDyve Pubget Overpricing