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10.1016/j.celrep.2016.04.009 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.009 C4870521!4870521!27134179     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (6): 1214-27 Nephropedia Template TP {{tp|p=27134179|t=2016. Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant |pdf=|usr=}}{{27134179}} gab.com Text Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27134179 #FOAvip Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the recipient during transplantation, but their impact on alloimmunity is unknown. Using mouse cardiac transplant models, we show that graft-versus-host recognition by passenger donor CD4 T cells markedly augments recipient cellular and humoral alloimmunity, resulting in more severe allograft vasculopathy and early graft failure. This augmentation is enhanced when donors were pre-sensitized to the recipient, is dependent upon avoidance of host NK cell recognition, and is partly due to provision of cognate help for allo-specific B cells from donor CD4 T cells recognizing B cell MHC class II in a peptide-degenerate manner. Passenger donor lymphocytes may therefore influence recipient alloimmune responses and represent a therapeutic target in solid organ transplantation. Twit Text FOAVip Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27134179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27134179 #FOAvip English Wikipedia <ref>{{Cite pmid|27134179}}</ref> Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant #MMPMID27134179 Harper I; Ali J; Harper S; Wlodek E; Alsughayyir J; Negus M; Qureshi M; Motalleb-Zadeh R; Saeb-Parsy K; Bolton E; Bradley J; Clatworthy M; Conlon T; Pettigrew G Cell Rep 2016[May]; 15 (6): 1214-27 PMID27134179show ga Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the recipient during transplantation, but their impact on alloimmunity is unknown. Using mouse cardiac transplant models, we show that graft-versus-host recognition by passenger donor CD4 T cells markedly augments recipient cellular and humoral alloimmunity, resulting in more severe allograft vasculopathy and early graft failure. This augmentation is enhanced when donors were pre-sensitized to the recipient, is dependent upon avoidance of host NK cell recognition, and is partly due to provision of cognate help for allo-specific B cells from donor CD4 T cells recognizing B cell MHC class II in a peptide-degenerate manner. Passenger donor lymphocytes may therefore influence recipient alloimmune responses and represent a therapeutic target in solid organ transplantation. äAugmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lym(epmc).pdf DeepDyve Pubget Overpricing