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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Springerplus 2016 ; 5 (ä): ä Nephropedia Template TP
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Membrane property and biofunction of phospholiposome incorporated with anomeric galactolipids #MMPMID27330921
Liu D; Zhang J; Xu S; Liu H
Springerplus 2016[]; 5 (ä): ä PMID27330921show ga
There has been increasing interest in the construction of liposomes containing a targeting reagent for target-specific drug delivery. Glycoconjugates that can be recognized by transmembrane glycoprotein receptors have been extensively used to form glyco-liposomal drug carriers. However, the impact of anomerism, which is a common identity of natural glycoconjugates, on the glyco-liposomal properties has been hardly probed in previous studies. Here we investigate the liposomal properties of phospholipid incorporated with a pair of anomeric galactolipids. The anomeric galacto-liposomes are characterized and their membrane fluidity, thermo-stability, DNA condensation efficiency and fluorescence leakage are comparatively tested. The in vitro cellular internalization effect of the galacto-liposomes is also demonstrated. This study suggests that anomerism might give distinct impact on the membrane properties and even biofunctions of glyco-liposomes.