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2016 ; 2016
(ä): 9685257
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Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps
militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats
#MMPMID27274781
Liu C
; Song J
; Teng M
; Zheng X
; Li X
; Tian Y
; Pan M
; Li Y
; Lee RJ
; Wang D
Oxid Med Cell Longev
2016[]; 2016
(ä): 9685257
PMID27274781
show ga
Cordyceps militaris has long been used as a crude drug and folk tonic food in
East Asia. The present study aims to evaluate the antidiabetic and antinephritic
effects of the aqueous extract of the Cordyceps militaris fruit body (CM) in
diet-streptozotocin- (STZ-) induced diabetic rats. During four weeks of
continuous oral administration of CM at doses of 0.5, 1.0, and 2.0?g/kg and
metformin at 100?mg/kg, the fasting blood glucose and bodyweight of each rat were
monitored. Hypoglycemic effects of CM on diabetic rats were indicated by
decreases in plasma glucose, food and water intake, and urine output. The
hypolipidemic activity of CM was confirmed by the normalization of total
cholesterol, triglycerides, and low- and high-density lipoprotein cholesterol in
diabetic rats. Inhibitory effects on albuminuria, creatinine, urea nitrogen, and
n-acetyl-?-d-glucosaminidase verified CM's renal protective activity in diabetic
rats. Furthermore, CM exerted beneficial modulation of inflammatory factors and
oxidative enzymes. Compared with untreated diabetic rats, CM decreased the
expression of phosphor-AKT and phosphor-GSK-3? in the kidneys. Altogether, via
attenuating oxidative stress, CM displayed antidiabetic and antinephritic
activities in diet-STZ-induced diabetic rats.