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10.14348/molcells.2016.0013 http://scihub22266oqcxt.onion/10.14348/molcells.2016.0013 C4870184!4870184!27117456     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cells 2016 ; 39 (5): 375-81 Nephropedia Template TP {{tp|p=27117456|t=2016. MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions |pdf=|usr=}}{{27117456}} gab.com Text MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=27117456 #FOAvip MicroRNAs (miRNAs) are small non-coding RNAs (?22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2?8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical ?seed sites? but also via non-canonical sites (?15?80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding ?nucleation bulges? and ?seed-like motifs?. We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression. Twit Text FOAVip MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=27117456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27117456 #FOAvip English Wikipedia <ref>{{Cite pmid|27117456}}</ref> MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions #MMPMID27117456 Seok H; Ham J; Jang ES; Chi SW Mol Cells 2016[May]; 39 (5): 375-81 PMID27117456show ga MicroRNAs (miRNAs) are small non-coding RNAs (?22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2?8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical ?seed sites? but also via non-canonical sites (?15?80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding ?nucleation bulges? and ?seed-like motifs?. We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression. äMicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Cano(epmc).pdf DeepDyve Pubget Overpricing