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2016 ; 72
(2
): 584-95
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Bayes and empirical Bayes methods for reduced rank regression models in matched
case-control studies
#MMPMID26575519
Satagopan JM
; Sen A
; Zhou Q
; Lan Q
; Rothman N
; Langseth H
; Engel LS
Biometrics
2016[Jun]; 72
(2
): 584-95
PMID26575519
show ga
Matched case-control studies are popular designs used in epidemiology for
assessing the effects of exposures on binary traits. Modern studies increasingly
enjoy the ability to examine a large number of exposures in a comprehensive
manner. However, several risk factors often tend to be related in a nontrivial
way, undermining efforts to identify the risk factors using standard analytic
methods due to inflated type-I errors and possible masking of effects.
Epidemiologists often use data reduction techniques by grouping the prognostic
factors using a thematic approach, with themes deriving from biological
considerations. We propose shrinkage-type estimators based on Bayesian
penalization methods to estimate the effects of the risk factors using these
themes. The properties of the estimators are examined using extensive
simulations. The methodology is illustrated using data from a matched
case-control study of polychlorinated biphenyls in relation to the etiology of
non-Hodgkin's lymphoma.