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10.1002/wsbm.138 http://scihub22266oqcxt.onion/10.1002/wsbm.138 C4869884!4869884!21755606     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21755606&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Wiley+Interdiscip+Rev+Syst+Biol+Med 2011 ; 3 (5): 588-605 Nephropedia Template TP {{tp|p=21755606|t=2011. Modeling the Control of Planar Cell Polarity |pdf=|usr=}}{{21755606}} gab.com Text Modeling the Control of Planar Cell Polarity JO: Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=21755606 #FOAvip A growing list of medically important developmental defects and disease mechanisms can be traced to disruption of the Planar Cell Polarity (PCP) pathway. The PCP system polarizes cells in epithelial sheets along an axis orthogonal to their apical-basal axis. Studies in the fruitfly, Drosophila, have led to the concept of a modular system controlling PCP. The components of the PCP signaling modules, and the effector systems with which they interact, function together to produce emergent patterns. Experimental methods allow the manipulation of individual PCP signaling molecules in specified groups of cells; these interventions not only perturb the polarization of the targeted cells at a subcellular level, but also perturb patterns of polarity at the multicellular level, often affecting nearby cells in characteristic ways. These kinds of experiments should, in principle, allow one to infer the architecture within and between modules, but the relationships between molecular interactions and tissue-level pattern are sufficiently complex that they defy intuitive understanding. Mathematical modeling has been an important tool to address these problems. This review explores the emergence of a local signaling hypothesis, and describes how a local intercellular signal, coupled with a directional cue, can give rise to global pattern. We will discuss the critical role mathematical modeling has played in guiding and interpreting experimental results, and speculate about future roles for mathematical modeling of PCP. Mathematical models at varying levels of abstraction have and are expected to continue contributing in distinct ways to understanding the regulation of PCP signaling. Twit Text FOAVip Modeling the Control of Planar Cell Polarity ????Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=21755606 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21755606 #FOAvip English Wikipedia <ref>{{Cite pmid|21755606}}</ref> Modeling the Control of Planar Cell Polarity #MMPMID21755606 Axelrod JD; Tomlin CJ Wiley Interdiscip Rev Syst Biol Med 2011[Sep]; 3 (5): 588-605 PMID21755606show ga A growing list of medically important developmental defects and disease mechanisms can be traced to disruption of the Planar Cell Polarity (PCP) pathway. The PCP system polarizes cells in epithelial sheets along an axis orthogonal to their apical-basal axis. Studies in the fruitfly, Drosophila, have led to the concept of a modular system controlling PCP. The components of the PCP signaling modules, and the effector systems with which they interact, function together to produce emergent patterns. Experimental methods allow the manipulation of individual PCP signaling molecules in specified groups of cells; these interventions not only perturb the polarization of the targeted cells at a subcellular level, but also perturb patterns of polarity at the multicellular level, often affecting nearby cells in characteristic ways. These kinds of experiments should, in principle, allow one to infer the architecture within and between modules, but the relationships between molecular interactions and tissue-level pattern are sufficiently complex that they defy intuitive understanding. Mathematical modeling has been an important tool to address these problems. This review explores the emergence of a local signaling hypothesis, and describes how a local intercellular signal, coupled with a directional cue, can give rise to global pattern. We will discuss the critical role mathematical modeling has played in guiding and interpreting experimental results, and speculate about future roles for mathematical modeling of PCP. Mathematical models at varying levels of abstraction have and are expected to continue contributing in distinct ways to understanding the regulation of PCP signaling. äModeling the Control of Planar Cell Polarity (epmc).pdf DeepDyve Pubget Overpricing