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10.5863/1551-6776-21.2.140

http://scihub22266oqcxt.onion/10.5863/1551-6776-21.2.140
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C4869771!4869771!27199621
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suck abstract from ncbi


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pmid27199621      J+Pediatr+Pharmacol+Ther 2016 ; 21 (2): 140-5
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  • Once Daily Dosing of Ceftriaxone and Metronidazole in Children With Perforated Appendicitis #MMPMID27199621
  • Lee JY; Ally S; Kelly B; Kays D; Thames L
  • J Pediatr Pharmacol Ther 2016[Mar]; 21 (2): 140-5 PMID27199621show ga
  • OBJECTIVES: The aim of this study was to compare hospital length of stay and rate of infectious complications in children with perforated appendicitis based on the postoperative antibiotic administered.METHODS: This study was a retrospective analysis of children with perforated appendicitis who underwent an appendectomy at a large academic medical center from 2008 to 2013. The primary outcome was hospital length of stay. The secondary outcomes were rates of abscess formation, wound infection, and 30-day readmissions.RESULTS: One hundred and twenty-three patients were included. Sixty-six patients (53%) were administered ceftriaxone and metronidazole once daily; 57 (47%) were administered other antibiotic regimens, which consisted of single, double, or triple antibiotic therapy with a beta-lactam backbone. There was no difference between the groups in terms of postoperative length of stay (5.7 versus 5.8 days, p = 0.83), postoperative abscess rate (8% versus 4%, p = 0.57), postoperative wound infection rate (5% versus 2%, p = 0.73), and 30-day readmissions (3% versus 11%, p = 0.19).CONCLUSIONS: While there was no statistically significant difierence in the outcomes evaluated, the rate of infectious complications was twofold higher in those given ceftriaxone and metronidazole than in others. A larger prospective randomized controlled trial is warranted to better understand the risks of using these agents.
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