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10.1126/science.aac9407 http://scihub22266oqcxt.onion/10.1126/science.aac9407 C4869713!4869713!26494174     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 350 (6263): 985-90 Nephropedia Template TP {{tp|p=26494174|t=2015. Patrolling Monocytes Control Tumor Metastasis to the Lung |pdf=|usr=}}{{26494174}} gab.com Text Patrolling Monocytes Control Tumor Metastasis to the Lung JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip The immune system plays an important role in regulating tumor growth and metastasis. For example, classical monocytes promote tumorigenesis and cancer metastasis; however, how nonclassical ?patrolling? monocytes interact with tumors is unknown. Here we show that patrolling monocytes are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack patrolling monocytes, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient patrolling monocytes into Nr4a1-deficient mice prevented tumor invasion in lung. Patrolling monocytes established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature and promoted natural killer cell recruitment and activation. Thus, patrolling monocytes contribute to cancer immunosurveillance and may be targets for cancer immunotherapy. Twit Text FOAVip Patrolling Monocytes Control Tumor Metastasis to the Lung ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26494174 #FOAvip English Wikipedia <ref>{{Cite pmid|26494174}}</ref> Patrolling Monocytes Control Tumor Metastasis to the Lung #MMPMID26494174 Hanna RN; Cekic C; Sag D; Tacke R; Thomas GD; Nowyhed H; Herrley E; Rasquinha N; McArdle S; Wu R; Peluso E; Metzger D; Ichinose H; Shaked I; Chodaczek G; Biswas SK; Hedrick CC Science 2015[Nov]; 350 (6263): 985-90 PMID26494174show ga The immune system plays an important role in regulating tumor growth and metastasis. For example, classical monocytes promote tumorigenesis and cancer metastasis; however, how nonclassical ?patrolling? monocytes interact with tumors is unknown. Here we show that patrolling monocytes are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack patrolling monocytes, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient patrolling monocytes into Nr4a1-deficient mice prevented tumor invasion in lung. Patrolling monocytes established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature and promoted natural killer cell recruitment and activation. Thus, patrolling monocytes contribute to cancer immunosurveillance and may be targets for cancer immunotherapy. äPatrolling Monocytes Control Tumor Metastasis to the Lung (epmc).pdf DeepDyve Pubget Overpricing