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10.1016/j.neubiorev.2015.12.014 http://scihub22266oqcxt.onion/10.1016/j.neubiorev.2015.12.014 C4869704!4869704!26748379     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Biobehav+Rev 2016 ; 62 (ä): 35-47 Nephropedia Template TP {{tp|p=26748379|t=2016. GABA-ergic Cell Therapy for Epilepsy: Advances, Limitations and Challenges |pdf=|usr=}}{{26748379}} gab.com Text GABA-ergic Cell Therapy for Epilepsy: Advances, Limitations and Challenges JO: Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=26748379 #FOAvip Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons and their axon terminals, and/or alterations in functional inhibition are conspicuous brain alterations believed to contribute to the persistence of seizures in acquired epilepsies such as temporal lobe epilepsy. This has steered a perception that replacement of lost GABA-ergic interneurons would improve inhibitory synaptic neurotransmission in the epileptic brain region and thereby reduce the occurrence of seizures. Indeed, studies using animal prototypes have reported that grafting of GABA-ergic progenitors derived from multiple sources into epileptic regions can reduce seizures. This review deliberates recent advances, limitations and challenges concerning the development of GABA-ergic cell therapy for epilepsy. The efficacy and limitations of grafts of primary GABA-ergic progenitors from the embryonic lateral ganglionic eminence and medial ganglionic eminence (MGE), neural stem/progenitor cells expanded from MGE, and MGE-like progenitors generated from human pluripotent stem cells for alleviating seizures and co-morbidities of epilepsy are conferred. Additional studies required for possible clinical application of GABA-ergic cell therapy for epilepsy are also summarized. Twit Text FOAVip GABA-ergic Cell Therapy for Epilepsy: Advances, Limitations and Challenges ????Neurosci Biobehav Rev http://www.kidney.de/pget.php?&tw=1&pmid=26748379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26748379 #FOAvip English Wikipedia <ref>{{Cite pmid|26748379}}</ref> GABA-ergic Cell Therapy for Epilepsy: Advances, Limitations and Challenges #MMPMID26748379 Shetty AK; Upadhya D Neurosci Biobehav Rev 2016[Mar]; 62 (ä): 35-47 PMID26748379show ga Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons and their axon terminals, and/or alterations in functional inhibition are conspicuous brain alterations believed to contribute to the persistence of seizures in acquired epilepsies such as temporal lobe epilepsy. This has steered a perception that replacement of lost GABA-ergic interneurons would improve inhibitory synaptic neurotransmission in the epileptic brain region and thereby reduce the occurrence of seizures. Indeed, studies using animal prototypes have reported that grafting of GABA-ergic progenitors derived from multiple sources into epileptic regions can reduce seizures. This review deliberates recent advances, limitations and challenges concerning the development of GABA-ergic cell therapy for epilepsy. The efficacy and limitations of grafts of primary GABA-ergic progenitors from the embryonic lateral ganglionic eminence and medial ganglionic eminence (MGE), neural stem/progenitor cells expanded from MGE, and MGE-like progenitors generated from human pluripotent stem cells for alleviating seizures and co-morbidities of epilepsy are conferred. Additional studies required for possible clinical application of GABA-ergic cell therapy for epilepsy are also summarized. äGABA-ergic Cell Therapy for Epilepsy: Advances, Limitations and Challe(epmc).pdf DeepDyve Pubget Overpricing