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10.1038/nrneph.2015.88 http://scihub22266oqcxt.onion/10.1038/nrneph.2015.88 C4869701!4869701!26055352     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Nephrol 2015 ; 11 (9): 535-45 Nephropedia Template TP {{tp|p=26055352|t=2015. Wnt/?-catenin signalling and podocyte dysfunction in proteinuric kidney disease |pdf=|usr=}}{{26055352}} gab.com Text Wnt/ -catenin signalling and podocyte dysfunction in proteinuric kidney disease JO: Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26055352 #FOAvip Podocytes are unique, highly specialized, terminally differentiated cells that are integral components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety of injuries and in response they undergo a series of changes ranging from hypertrophy, autophagy, dedifferentiation, mesenchymal transition and detachment to apoptosis, depending on the nature and extent of the insult. Emerging evidence indicates that Wnt/?-catenin signalling has a central role in mediating podocyte dysfunction and proteinuria. Wnts are induced and ?-catenin is activated in podocytes in various proteinuric kidney diseases. Genetic or pharmacologic activation of ?-catenin is sufficient to impair podocyte integrity and causes proteinuria in healthy mice, whereas podocyte-specific ablation of ?-catenin protects against proteinuria after kidney injury. Mechanistically, Wnt/?-catenin controls the expression of several key mediators implicated in podocytopathies, including Snail1, the renin?angiotensin system and matrix metalloproteinase 7. Wnt/?-catenin also negatively regulates Wilms tumour protein, a crucial transcription factor that safeguards podocyte integrity. Targeted inhibition of Wnt/?-catenin signalling preserves podocyte integrity and ameliorates proteinuria in animal models. This Review highlights advances in our understanding of the pathomechanisms of Wnt/?-catenin signalling in mediating podocyte injury, and describes the therapeutic potential of targeting this pathway for the treatment of proteinuric kidney disease. Twit Text FOAVip Wnt/ -catenin signalling and podocyte dysfunction in proteinuric kidney disease ????Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26055352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26055352 #FOAvip English Wikipedia <ref>{{Cite pmid|26055352}}</ref> Wnt/?-catenin signalling and podocyte dysfunction in proteinuric kidney disease #MMPMID26055352 Zhou L; Liu Y Nat Rev Nephrol 2015[Sep]; 11 (9): 535-45 PMID26055352show ga Podocytes are unique, highly specialized, terminally differentiated cells that are integral components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety of injuries and in response they undergo a series of changes ranging from hypertrophy, autophagy, dedifferentiation, mesenchymal transition and detachment to apoptosis, depending on the nature and extent of the insult. Emerging evidence indicates that Wnt/?-catenin signalling has a central role in mediating podocyte dysfunction and proteinuria. Wnts are induced and ?-catenin is activated in podocytes in various proteinuric kidney diseases. Genetic or pharmacologic activation of ?-catenin is sufficient to impair podocyte integrity and causes proteinuria in healthy mice, whereas podocyte-specific ablation of ?-catenin protects against proteinuria after kidney injury. Mechanistically, Wnt/?-catenin controls the expression of several key mediators implicated in podocytopathies, including Snail1, the renin?angiotensin system and matrix metalloproteinase 7. Wnt/?-catenin also negatively regulates Wilms tumour protein, a crucial transcription factor that safeguards podocyte integrity. Targeted inhibition of Wnt/?-catenin signalling preserves podocyte integrity and ameliorates proteinuria in animal models. This Review highlights advances in our understanding of the pathomechanisms of Wnt/?-catenin signalling in mediating podocyte injury, and describes the therapeutic potential of targeting this pathway for the treatment of proteinuric kidney disease. äWnt/?-catenin signalling and podocyte dysfunction in proteinuric kidne(epmc).pdf DeepDyve Pubget Overpricing