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10.2147/COPD.S105988

http://scihub22266oqcxt.onion/10.2147/COPD.S105988
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suck abstract from ncbi


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pmid27274220
      Int+J+Chron+Obstruct+Pulmon+Dis 2016 ; 11 (ä): 991-7
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  • Comparison of pulmonary function in patients with COPD, asthma-COPD overlap syndrome, and asthma with airflow limitation #MMPMID27274220
  • Kitaguchi Y ; Yasuo M ; Hanaoka M
  • Int J Chron Obstruct Pulmon Dis 2016[]; 11 (ä): 991-7 PMID27274220 show ga
  • BACKGROUND: This study was conducted in order to investigate the differences in the respiratory physiology of patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome (ACOS), and asthma with airflow limitation (asthma FL(+)). METHODS: The medical records for a series of all stable patients with persistent airflow limitation due to COPD, ACOS, or asthma were retrospectively reviewed and divided into the COPD group (n=118), the ACOS group (n=32), and the asthma FL(+) group (n=27). All the patients underwent chest high-resolution computed tomography (HRCT) and pulmonary function tests, including respiratory impedance. RESULTS: The low attenuation area score on chest HRCT was significantly higher in the COPD group than in the ACOS group (9.52±0.76 vs 5.09±1.16, P<0.01). The prevalence of bronchial wall thickening on chest HRCT was significantly higher in the asthma FL(+) group than in the COPD group (55.6% vs 25.0%, P<0.01). In pulmonary function, forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate were significantly higher in the asthma FL(+) group than in the ACOS group (76.28%±2.54% predicted vs 63.43%±3.22% predicted, P<0.05 and 74.40%±3.16% predicted vs 61.08%±3.54% predicted, P<0.05, respectively). Although residual volume was significantly lower in the asthma FL(+) group than in the COPD group (112.05%±4.34% predicted vs 137.38%±3.43% predicted, P<0.01) and the ACOS group (112.05%±4.34% predicted vs148.46%±6.25% predicted, P<0.01), there were no significant differences in functional residual capacity or total lung capacity. The increase in FEV1 in response to short-acting ?2-agonists was significantly greater in the ACOS group than in the COPD group (229±29 mL vs 72±10 mL, P<0.01) and the asthma FL(+) group (229±29 mL vs 153±21 mL, P<0.05). Regarding respiratory impedance, resistance at 5 Hz and resistance at 20 Hz, which are oscillatory parameters of respiratory resistance, were significantly higher in the asthma FL(+) group than in the COPD group at the whole-breath (4.29±0.30 cmH2O/L/s vs 3.41±0.14 cmH2O/L/s, P<0.01 and 3.50±0.24 cmH2O/L/s vs 2.68±0.10 cmH2O/L/s, P<0.01, respectively), expiratory, and inspiratory phases. CONCLUSION: Although persistent airflow limitation occurs in patients with COPD, ACOS, and asthma FL(+), they may have distinct characteristics of the respiratory physiology and different responsiveness to bronchodilators.
  • |Administration, Inhalation [MESH]
  • |Adrenergic beta-2 Receptor Agonists/administration & dosage [MESH]
  • |Aged [MESH]
  • |Airway Resistance [MESH]
  • |Asthma/diagnosis/drug therapy/*physiopathology [MESH]
  • |Bronchodilator Agents/administration & dosage [MESH]
  • |Female [MESH]
  • |Forced Expiratory Volume [MESH]
  • |Humans [MESH]
  • |Lung/diagnostic imaging/drug effects/*physiopathology [MESH]
  • |Male [MESH]
  • |Medical Records [MESH]
  • |Metered Dose Inhalers [MESH]
  • |Peak Expiratory Flow Rate [MESH]
  • |Phenotype [MESH]
  • |Procaterol/administration & dosage [MESH]
  • |Pulmonary Disease, Chronic Obstructive/diagnosis/drug therapy/*physiopathology [MESH]
  • |Pulmonary Emphysema/diagnosis/drug therapy/*physiopathology [MESH]
  • |Retrospective Studies [MESH]
  • |Spirometry [MESH]
  • |Syndrome [MESH]


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