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10.1038/nri.2015.16 http://scihub22266oqcxt.onion/10.1038/nri.2015.16 C4869523!4869523!26852928     free     free     free       Nat+Rev+Immunol 2016 ; 16 (3): 193-201 Nephropedia Template TP {{tp|p=26852928|t=2016. T-cell Migration, Search Strategies and Mechanisms |pdf=|usr=}}{{26852928}} gab.com Text T-cell Migration, Search Strategies and Mechanisms JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26852928 #FOAvip T cell migration is essential for T cell responses, allowing for detection of cognate antigen at the surface of an Antigen-Presenting Cell (APC) and for interactions with other cells involved in the immune response. Although appearing random, growing evidence supports that T cell motility patterns are strategic and governed by mechanisms that are optimized for both activation-stage and environment-specific attributes. In this Opinion Article, we will discuss how to understand the combined effects of T cell- intrinsic and -extrinsic forces upon these motility patterns when viewed in highly complex tissues filled with other cells involved in parallel motility. In particular, we will examine how insights from ?search theory? describe T cell movement across exploitation-exploration gradients, in the context of activation versus effector function and in the context of lymph nodes versus peripheral tissues. Twit Text FOAVip T-cell Migration, Search Strategies and Mechanisms ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26852928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26852928 #FOAvip English Wikipedia <ref>{{Cite pmid|26852928}}</ref> T-cell Migration, Search Strategies and Mechanisms #MMPMID26852928 Krummel MF; Bartumeus F; Gérard A Nat Rev Immunol 2016[Mar]; 16 (3): 193-201 PMID26852928show ga T cell migration is essential for T cell responses, allowing for detection of cognate antigen at the surface of an Antigen-Presenting Cell (APC) and for interactions with other cells involved in the immune response. Although appearing random, growing evidence supports that T cell motility patterns are strategic and governed by mechanisms that are optimized for both activation-stage and environment-specific attributes. In this Opinion Article, we will discuss how to understand the combined effects of T cell- intrinsic and -extrinsic forces upon these motility patterns when viewed in highly complex tissues filled with other cells involved in parallel motility. In particular, we will examine how insights from ?search theory? describe T cell movement across exploitation-exploration gradients, in the context of activation versus effector function and in the context of lymph nodes versus peripheral tissues. äT-cell Migration, Search Strategies and Mechanisms (epmc).pdf DeepDyve Pubget Overpricing