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10.5812/traumamon.19649

http://scihub22266oqcxt.onion/10.5812/traumamon.19649
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C4869432!4869432!27218042
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suck abstract from ncbi


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pmid27218042      Trauma+Mon 2016 ; 21 (1): ä
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  • Efficacy of Intravenous Paracetamol Versus Intravenous Morphine in Acute Limb Trauma #MMPMID27218042
  • Jalili M; Mozaffarpour Noori A; Sedaghat M; Safaie A
  • Trauma Mon 2016[Feb]; 21 (1): ä PMID27218042show ga
  • Background:: Efficient pain management is one of the most important components of care in the field of emergency medicine. Objectives:: This study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. Patients and Methods:: In a randomized double-blinded clinical trial, all patients (aged 18 years and older) with acute limb trauma and a pain score of greater than 3/10 in the emergency department were recruited; they received either 1 g intravenous paracetamol or 0.1 mg/kg intravenous morphine sulfate over 15 minutes. The primary outcome was the pain score measured on a numerical rating scale at 0, 15 and 30 minutes after commencing drug administration. The requirement for rescue analgesia and the frequency of adverse reactions were also recorded. Results:: Sixty patients randomly received either IV paracetamol (n = 30) or IV morphine (n = 30). The mean reduction in numerical rating scale pain intensity scores at 30 minutes was 3.86 (± 1.61) for paracetamol, and 2.16 (± 1.39) for morphine. However, pain relief was significantly higher in the paracetamol group compared to the morphine group (P < 0.001). Four patients in the paracetamol group and 15 patients in the morphine group needed rescue analgesia and the difference was significant (P = 0.05). Conclusions:: Intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. Further larger studies are required.
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