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10.15252/embj.201593118 http://scihub22266oqcxt.onion/10.15252/embj.201593118 C4868951!4868951!26988032     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2016 ; 35 (10): 1058-76 Nephropedia Template TP {{tp|p=26988032|t=2016. eIF4A inactivates TORC1 in response to amino acid starvation |pdf=|usr=}}{{26988032}} gab.com Text eIF4A inactivates TORC1 in response to amino acid starvation JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26988032 #FOAvip Amino acids regulate TOR complex 1 (TORC1) via two counteracting mechanisms, one activating and one inactivating. The presence of amino acids causes TORC1 recruitment to lysosomes where TORC1 is activated by binding Rheb. How the absence of amino acids inactivates TORC1 is less well understood. Amino acid starvation recruits the TSC1/TSC2 complex to the vicinity of TORC1 to inhibit Rheb; however, the upstream mechanisms regulating TSC2 are not known. We identify here the eIF4A?containing eIF4F translation initiation complex as an upstream regulator of TSC2 in response to amino acid withdrawal in Drosophila. We find that TORC1 and translation preinitiation complexes bind each other. Cells lacking eIF4F components retain elevated TORC1 activity upon amino acid removal. This effect is specific for eIF4F and not a general consequence of blocked translation. This study identifies specific components of the translation machinery as important mediators of TORC1 inactivation upon amino acid removal. Twit Text FOAVip eIF4A inactivates TORC1 in response to amino acid starvation ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26988032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988032 #FOAvip English Wikipedia <ref>{{Cite pmid|26988032}}</ref> eIF4A inactivates TORC1 in response to amino acid starvation #MMPMID26988032 Tsokanos F; Albert M; Demetriades C; Spirohn K; Boutros M; Teleman AA EMBO J 2016[May]; 35 (10): 1058-76 PMID26988032show ga Amino acids regulate TOR complex 1 (TORC1) via two counteracting mechanisms, one activating and one inactivating. The presence of amino acids causes TORC1 recruitment to lysosomes where TORC1 is activated by binding Rheb. How the absence of amino acids inactivates TORC1 is less well understood. Amino acid starvation recruits the TSC1/TSC2 complex to the vicinity of TORC1 to inhibit Rheb; however, the upstream mechanisms regulating TSC2 are not known. We identify here the eIF4A?containing eIF4F translation initiation complex as an upstream regulator of TSC2 in response to amino acid withdrawal in Drosophila. We find that TORC1 and translation preinitiation complexes bind each other. Cells lacking eIF4F components retain elevated TORC1 activity upon amino acid removal. This effect is specific for eIF4F and not a general consequence of blocked translation. This study identifies specific components of the translation machinery as important mediators of TORC1 inactivation upon amino acid removal. äeIF4A inactivates TORC1 in response to amino acid starvation (epmc).pdf DeepDyve Pubget Overpricing