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10.4049/jimmunol.1501740 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501740 C4868785!4868785!27001954     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (9): 3631-41 Nephropedia Template TP {{tp|p=27001954|t=2016. TGF-?-induced regulatory T cells directly suppress B cell responses through a non-cytotoxic mechanism |pdf=|usr=}}{{27001954}} gab.com Text TGF- -induced regulatory T cells directly suppress B cell responses through a non-cytotoxic mechanism JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27001954 #FOAvip Foxp3+ regulatory T cells (Treg) playing a crucial role in the maintenance of immune tolerance and prevention of autoimmune diseases consist of thymus-derived naturally-occurring CD4+Foxp3+ Treg cells (nTreg) and those that can be induced ex vivo with TGF-? (iTreg). Although both Treg subsets share similar phenotypes and functional characteristics, they also have potential biologic differences on their biology. The role of iTreg in regulating B cells remains unclear so far. The suppression assays of Treg subsets on activation, proliferation and antibodies production of B cells were measured using a Treg and B cell co-culture system in vitro. Transwell and antibody blockade experiments were performed to assess the roles of cell contact and soluble cytokines. Treg were adoptively transferred to lupus mice to assess in vivo effects on B cells. Like nTreg, iTreg subset also directly suppressed activation and proliferation of B cells. nTreg subset suppressed B cell responses through cytotoxic manner related to expression of Granzyme A, Granzyme B and Perforin; while the role of iTreg subset on B cells did not involve in cytotoxic action, but depending on TGF-? signaling. Furthermore, iTreg subset can significantly suppress antibody produced by lupus B cells in vitro. Comparison experiments using autoantibodies microarrays demonstrated that adoptive transfer of iTreg had a superior effect than nTreg subset on suppressing lupus B cell responses in vivo. Our data implicate a role and advantage of iTreg subset in treating B cell-mediated autoimmune diseases, boosting the translational potential of these findings. Twit Text FOAVip TGF- -induced regulatory T cells directly suppress B cell responses through a non-cytotoxic mechanism ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27001954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27001954 #FOAvip English Wikipedia <ref>{{Cite pmid|27001954}}</ref> TGF-?-induced regulatory T cells directly suppress B cell responses through a non-cytotoxic mechanism #MMPMID27001954 Xu A; Liu Y; Chen W; Wang J; Xue Y; Huang F; Rong l; Lin J; Liu D; Yan M; Li QZ; Li B; Song J; Olsen N; Zheng SG J Immunol 2016[May]; 196 (9): 3631-41 PMID27001954show ga Foxp3+ regulatory T cells (Treg) playing a crucial role in the maintenance of immune tolerance and prevention of autoimmune diseases consist of thymus-derived naturally-occurring CD4+Foxp3+ Treg cells (nTreg) and those that can be induced ex vivo with TGF-? (iTreg). Although both Treg subsets share similar phenotypes and functional characteristics, they also have potential biologic differences on their biology. The role of iTreg in regulating B cells remains unclear so far. The suppression assays of Treg subsets on activation, proliferation and antibodies production of B cells were measured using a Treg and B cell co-culture system in vitro. Transwell and antibody blockade experiments were performed to assess the roles of cell contact and soluble cytokines. Treg were adoptively transferred to lupus mice to assess in vivo effects on B cells. Like nTreg, iTreg subset also directly suppressed activation and proliferation of B cells. nTreg subset suppressed B cell responses through cytotoxic manner related to expression of Granzyme A, Granzyme B and Perforin; while the role of iTreg subset on B cells did not involve in cytotoxic action, but depending on TGF-? signaling. Furthermore, iTreg subset can significantly suppress antibody produced by lupus B cells in vitro. Comparison experiments using autoantibodies microarrays demonstrated that adoptive transfer of iTreg had a superior effect than nTreg subset on suppressing lupus B cell responses in vivo. Our data implicate a role and advantage of iTreg subset in treating B cell-mediated autoimmune diseases, boosting the translational potential of these findings. äTGF-?-induced regulatory T cells directly suppress B cell responses th(epmc).pdf DeepDyve Pubget Overpricing