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10.18632/oncotarget.6740 http://scihub22266oqcxt.onion/10.18632/oncotarget.6740 C4868747!4868747 !26716418     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26716418 &cmd=llinks): Failed to open stream: HTTP request failed! 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A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers |pdf=|usr=}}{{26716418 }} gab.com Text A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716418 #FOAvip Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it affects other solid cancers. Here we utilized multi-photon laser scanning microscopy and Second Harmonic Generation to identify alterations to collagen fiber structure within the tumor stroma of head & neck, esophageal and colorectal cancers. Image segmentation algorithms were then applied to quantitatively characterize these morphological changes, showing that elongated collagen fibers significantly correlated with poor clinical outcome (Log Rank p < 0.05). We used TGF-? treatment to model fibroblast conversion to smooth muscle actin SMA-positive cancer associated fibroblasts (CAFs) and found that these cells induce the formation of elongated collagen fibers in vivo. However, proteomic/transcriptomic analysis of SMA-positive CAFs cultured ex-vivo showed significant heterogeneity in the expression of genes with collagen fibril organizing gene ontology. Notably, stratifying patients according to stromal SMA-positivity and collagen fiber elongation was found to provide a highly significant correlation with poor survival in all 3 cancer types (Log Rank p ? 0.003). In summary, we show that increased collagen fiber length correlates with poor patient survival in multiple tumor types and that only a sub-set of SMA-positive CAFs can mediate the formation of this collagen structure. Twit Text FOAVip A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26716418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26716418 #FOAvip English Wikipedia <ref>{{Cite pmid|26716418 }}</ref> A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers #MMPMID26716418 Hanley CJ ; Noble F ; Ward M ; Bullock M ; Drifka C ; Mellone M ; Manousopoulou A ; Johnston HE ; Hayden A ; Thirdborough S ; Liu Y ; Smith DM ; Mellows T ; Kao WJ ; Garbis SD ; Mirnezami A ; Underwood TJ ; Eliceiri KW ; Thomas GJ Oncotarget 2016[Feb]; 7 (5 ): 6159-74 PMID26716418 show ga Collagen structure has been shown to influence tumor cell invasion, metastasis and clinical outcome in breast cancer. However, it remains unclear how it affects other solid cancers. Here we utilized multi-photon laser scanning microscopy and Second Harmonic Generation to identify alterations to collagen fiber structure within the tumor stroma of head & neck, esophageal and colorectal cancers. Image segmentation algorithms were then applied to quantitatively characterize these morphological changes, showing that elongated collagen fibers significantly correlated with poor clinical outcome (Log Rank p < 0.05). We used TGF-? treatment to model fibroblast conversion to smooth muscle actin SMA-positive cancer associated fibroblasts (CAFs) and found that these cells induce the formation of elongated collagen fibers in vivo. However, proteomic/transcriptomic analysis of SMA-positive CAFs cultured ex-vivo showed significant heterogeneity in the expression of genes with collagen fibril organizing gene ontology. Notably, stratifying patients according to stromal SMA-positivity and collagen fiber elongation was found to provide a highly significant correlation with poor survival in all 3 cancer types (Log Rank p ? 0.003). In summary, we show that increased collagen fiber length correlates with poor patient survival in multiple tumor types and that only a sub-set of SMA-positive CAFs can mediate the formation of this collagen structure. |Cancer-Associated Fibroblasts/*metabolism [MESH] |Collagen/*metabolism [MESH] |Extracellular Matrix/*metabolism [MESH] |Fibroblasts/*metabolism [MESH] |Humans [MESH] |Myofibroblasts/*metabolism [MESH] |Neoplasms/*metabolism/pathology [MESH] |Prognosis [MESH] |Survival Rate [MESH]A subset of myofibroblastic cancer-associated fibroblasts regulate col(epmc).pdf DeepDyve Pubget Overpricing