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10.18632/oncotarget.6835 http://scihub22266oqcxt.onion/10.18632/oncotarget.6835 C4868743!4868743 !26756218     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26756218 &cmd=llinks): Failed to open stream: HTTP request failed! 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Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair |pdf=|usr=}}{{26756218 }} gab.com Text Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26756218 #FOAvip Retinoblastoma (RB) arises from the retina, and its growth usually occurs under the retina and toward the vitreous. Ideal therapy should aim to inhibit the tumor and protect neural cells, increasing the patient's life span and quality of life. Previous studies have demonstrated that Thrombospondin-1 (TSP-1) is associated with neurogenesis, neovascularization and tumorigenesis. However, at present, the bioactivity of TSP-1 in retinoblastoma has not been defined. Herein, we demonstrated that TSP-1 was silenced in RB cell lines and clinical tumor samples. HDAC inhibitor, Trichostatin A (TSA), could notably transcriptionally up-regulate TSP-1 in RB cells, WERI-Rb1 cells and Y79 cells. Moreover, we found human recombinant TSP-1 (hTSP-1) could significantly inhibit the cell viability of RB cells both in vitro and in vivo. Interestingly, hTSP-1 could significantly induce the expression of ?-H2AX, a well-characterized in situ marker of DNA double-strand breaks (DSBs) in RB cells. The DNA NHEJ pathway in WERI-Rb1 cells could be significantly inhibited by hTSP-1. A mutation in Rb1 might be involved in the hTSP-1-medicated ?-H2AX increasing in WERI-Rb1 cells. Furthermore, hTSP-1 could inhibit RB cells while promoting retinal neurocyte survival in the neuronal and retinoblastoma cell co-culture system. As such, TSP-1 may become a therapeutic target for treatment of retinoblastoma. Twit Text FOAVip Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26756218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26756218 #FOAvip English Wikipedia <ref>{{Cite pmid|26756218 }}</ref> Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair #MMPMID26756218 Chen P ; Yu N ; Zhang Z ; Zhang P ; Yang Y ; Wu N ; Xu L ; Zhang J ; Ge J ; Yu K ; Zhuang J Oncotarget 2016[Feb]; 7 (5 ): 6105-20 PMID26756218 show ga Retinoblastoma (RB) arises from the retina, and its growth usually occurs under the retina and toward the vitreous. Ideal therapy should aim to inhibit the tumor and protect neural cells, increasing the patient's life span and quality of life. Previous studies have demonstrated that Thrombospondin-1 (TSP-1) is associated with neurogenesis, neovascularization and tumorigenesis. However, at present, the bioactivity of TSP-1 in retinoblastoma has not been defined. Herein, we demonstrated that TSP-1 was silenced in RB cell lines and clinical tumor samples. HDAC inhibitor, Trichostatin A (TSA), could notably transcriptionally up-regulate TSP-1 in RB cells, WERI-Rb1 cells and Y79 cells. Moreover, we found human recombinant TSP-1 (hTSP-1) could significantly inhibit the cell viability of RB cells both in vitro and in vivo. Interestingly, hTSP-1 could significantly induce the expression of ?-H2AX, a well-characterized in situ marker of DNA double-strand breaks (DSBs) in RB cells. The DNA NHEJ pathway in WERI-Rb1 cells could be significantly inhibited by hTSP-1. A mutation in Rb1 might be involved in the hTSP-1-medicated ?-H2AX increasing in WERI-Rb1 cells. Furthermore, hTSP-1 could inhibit RB cells while promoting retinal neurocyte survival in the neuronal and retinoblastoma cell co-culture system. As such, TSP-1 may become a therapeutic target for treatment of retinoblastoma. |*DNA Breaks, Double-Stranded [MESH] |Acetylation/drug effects [MESH] |Animals [MESH] |Histones/genetics/*metabolism [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Molecular Targeted Therapy [MESH] |Random Allocation [MESH] |Retinoblastoma Protein/*metabolism [MESH] |Retinoblastoma/drug therapy/genetics/metabolism/*therapy [MESH] |Thrombospondin 1/*administration & dosage/genetics/pharmacology [MESH] |Tumor Cells, Cultured [MESH]Thrombospondin-1 might be a therapeutic target to suppress RB cells by(epmc).pdf DeepDyve Pubget Overpricing