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10.4049/jimmunol.1502614 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502614 C4868662!4868662 !27016608     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27016608 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Immunol 2016 ; 196 (9 ): 3542-6 Nephropedia Template TP {{tp|p=27016608 |t=2016. Cutting Edge: Integrin ?4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis |pdf=|usr=}}{{27016608 }} gab.com Text Cutting Edge: Integrin 4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27016608 #FOAvip The neutralization of integrin ?4 (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell-targeting therapies. Twit Text FOAVip Cutting Edge: Integrin 4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27016608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27016608 #FOAvip English Wikipedia <ref>{{Cite pmid|27016608 }}</ref> Cutting Edge: Integrin ?4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis #MMPMID27016608 Glatigny S ; Wagner CA ; Bettelli E J Immunol 2016[May]; 196 (9 ): 3542-6 PMID27016608 show ga The neutralization of integrin ?4 (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology. Our study underscores the importance of looking at the dual role of B cells in CNS autoimmunity and provides important perspectives regarding the efficacy and side effects associated with Itga4 neutralization and other B cell-targeting therapies. |Animals [MESH] |B-Lymphocytes, Regulatory/*immunology/physiology [MESH] |Cell Movement [MESH] |Central Nervous System/*immunology [MESH] |Encephalomyelitis, Autoimmune, Experimental/*immunology/prevention & control [MESH] |Humans [MESH] |Integrin alpha4/genetics/*immunology [MESH] |Mice [MESH] |Multiple Sclerosis/immunology [MESH]Cutting Edge: Integrin ?4 Is Required for Regulatory B Cell Control of(epmc).pdf DeepDyve Pubget Overpricing