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10.4049/jimmunol.1501176 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501176 C4868656!4868656!26994221     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (9): 3653-64 Nephropedia Template TP {{tp|p=26994221|t=2016. Transient surface CCR5 expression by naïve CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response1 |pdf=|usr=}}{{26994221}} gab.com Text Transient surface CCR5 expression by naïve CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26994221 #FOAvip In inflamed lymph nodes, Ag-specific CD4+ and CD8+ T cells encounter Ag-bearing DCs and, together, this complex enhances the release of CCL3 and CCL4 that facilitate additional interaction with naïve CD8+ T cells. While blocking CCL3 and CCL4 has no effect on primary CD8+ T cell responses, it dramatically impairs the development of memory CD8+ T cell upon Ag re-challenge. Despite the absence of detectable surface CCR5 expression on circulating native CD8+ T cells, these data imply that naïve CD8+ T cells are capable of expressing surface CCR5 prior to cognate antigen-induced TCR signaling in inflamed lymph nodes; however, the molecular mechanisms have not been characterized to date. Here, we show that CCR5, the receptor for CCL3 and CCL4, can be transiently upregulated on a subset of naïve CD8+ T cells and this upregulation is dependent on direct contact with the HEV in inflamed lymph node (LN)3. Binding of CD62L and CD11a on T cells to their ligands CD34 and CD54 on the HEV can be enhanced during inflammation. This enhanced binding and subsequent signaling promote the translocation of CCR5 molecules from intracellular vesicles to the surface of the CD8+ T cell. The upregulation of CCR5 on the surface of the CD8+ T cells increases the number of contacts with antigen-bearing DCs, which ultimately results in increased CD8+ T cell response to Ag re-challenge. Twit Text FOAVip Transient surface CCR5 expression by naïve CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26994221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26994221 #FOAvip English Wikipedia <ref>{{Cite pmid|26994221}}</ref> Transient surface CCR5 expression by naïve CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response1 #MMPMID26994221 Askew D; Su CA; Barkauskas DS; Dorand RD; Myers J; Liou R; Nthale J; Huang AY J Immunol 2016[May]; 196 (9): 3653-64 PMID26994221show ga In inflamed lymph nodes, Ag-specific CD4+ and CD8+ T cells encounter Ag-bearing DCs and, together, this complex enhances the release of CCL3 and CCL4 that facilitate additional interaction with naïve CD8+ T cells. While blocking CCL3 and CCL4 has no effect on primary CD8+ T cell responses, it dramatically impairs the development of memory CD8+ T cell upon Ag re-challenge. Despite the absence of detectable surface CCR5 expression on circulating native CD8+ T cells, these data imply that naïve CD8+ T cells are capable of expressing surface CCR5 prior to cognate antigen-induced TCR signaling in inflamed lymph nodes; however, the molecular mechanisms have not been characterized to date. Here, we show that CCR5, the receptor for CCL3 and CCL4, can be transiently upregulated on a subset of naïve CD8+ T cells and this upregulation is dependent on direct contact with the HEV in inflamed lymph node (LN)3. Binding of CD62L and CD11a on T cells to their ligands CD34 and CD54 on the HEV can be enhanced during inflammation. This enhanced binding and subsequent signaling promote the translocation of CCR5 molecules from intracellular vesicles to the surface of the CD8+ T cell. The upregulation of CCR5 on the surface of the CD8+ T cells increases the number of contacts with antigen-bearing DCs, which ultimately results in increased CD8+ T cell response to Ag re-challenge. äTransient surface CCR5 expression by naïve CD8+ T cells within inflame(epmc).pdf DeepDyve Pubget Overpricing