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10.4049/jimmunol.1500595 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500595 C4868642!4868642!27009492     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (9): 3665-76 Nephropedia Template TP {{tp|p=27009492|t=2016. Developmental progression and inter-relationship of central and effector regulatory T cell subsets |pdf=|usr=}}{{27009492}} gab.com Text Developmental progression and inter-relationship of central and effector regulatory T cell subsets JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27009492 #FOAvip Resting central Tregs (cTregs) and activated effector Tregs (eTregs) are required for self-tolerance, but the heterogeneity and relationships within and between phenotypically distinct subsets of cTregs and eTregs are poorly understood. By extensive immune profiling and deep sequencing of TCR? V-regions, two subsets of cTregs, based on expression of Ly-6C, and three subsets of eTregs, based on distinctive expression of CD62L, CD69, and CD103, were identified. Ly-6C+ cTregs exhibited lower basal activation, expressed on average lower affinity TCRs, and less efficiently developed into eTregs when compared to Ly-6C? cTregs. The dominant TCR V?s of Ly-6C+ cTregs were shared by eTregs at a low frequency. A single TCR clonotype was also identified that was largely restricted to Ly-6C+ cTregs, even under conditions that promoted the development of eTregs. Collectively, these findings indicate that some Ly-6C+ cTregs may persist as a lymphoid-specific subset, with minimal potential to develop into highly activated eTregs, while other cTregs readily develop into eTregs. In contrast, subsets of CD62Llo eTregs showed higher clonal expansion and were more highly inter-related than cTreg subsets based on their TCR? repertoires, but exhibited varied immune profiles. The CD62Llo CD69? CD103? eTreg subset displayed properties of a transitional intermediate between cTregs and more activated eTreg subsets. Thus, eTregs subsets appear to exhibit substantial flexibility, likely in response to environmental cues, to adopt defined immune profiles that are expected to optimize suppression of autoreactive T cells. Twit Text FOAVip Developmental progression and inter-relationship of central and effector regulatory T cell subsets ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27009492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27009492 #FOAvip English Wikipedia <ref>{{Cite pmid|27009492}}</ref> Developmental progression and inter-relationship of central and effector regulatory T cell subsets #MMPMID27009492 Toomer KH; Yuan X; Yang J; Dee MJ; Yu A; Malek TR J Immunol 2016[May]; 196 (9): 3665-76 PMID27009492show ga Resting central Tregs (cTregs) and activated effector Tregs (eTregs) are required for self-tolerance, but the heterogeneity and relationships within and between phenotypically distinct subsets of cTregs and eTregs are poorly understood. By extensive immune profiling and deep sequencing of TCR? V-regions, two subsets of cTregs, based on expression of Ly-6C, and three subsets of eTregs, based on distinctive expression of CD62L, CD69, and CD103, were identified. Ly-6C+ cTregs exhibited lower basal activation, expressed on average lower affinity TCRs, and less efficiently developed into eTregs when compared to Ly-6C? cTregs. The dominant TCR V?s of Ly-6C+ cTregs were shared by eTregs at a low frequency. A single TCR clonotype was also identified that was largely restricted to Ly-6C+ cTregs, even under conditions that promoted the development of eTregs. Collectively, these findings indicate that some Ly-6C+ cTregs may persist as a lymphoid-specific subset, with minimal potential to develop into highly activated eTregs, while other cTregs readily develop into eTregs. In contrast, subsets of CD62Llo eTregs showed higher clonal expansion and were more highly inter-related than cTreg subsets based on their TCR? repertoires, but exhibited varied immune profiles. The CD62Llo CD69? CD103? eTreg subset displayed properties of a transitional intermediate between cTregs and more activated eTreg subsets. Thus, eTregs subsets appear to exhibit substantial flexibility, likely in response to environmental cues, to adopt defined immune profiles that are expected to optimize suppression of autoreactive T cells. äDevelopmental progression and inter-relationship of central and effect(epmc).pdf DeepDyve Pubget Overpricing