Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1502410 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502410 C4868634!4868634!27029586     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (10): 4237-45 Nephropedia Template TP {{tp|p=27029586|t=2016. The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation |pdf=|usr=}}{{27029586}} gab.com Text The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27029586 #FOAvip The microtubule-associated protein Lissencephaly 1 (Lis1) is a key regulator of cell division during stem cell renewal and differentiation. In this study, we examined the role of Lis1 in T lymphocyte homeostasis and fate diversification in response to microbial infection. T cell-specific deletion of Lis1 resulted in depletion of the peripheral CD4+ and CD8+ T lymphocyte pool, owing to a loss of homeostatic, cytokine-induced proliferation. By contrast, cognate antigen-triggered proliferation was much less affected, enabling Lis1-deficient CD8+ T cells to differentiate into terminal effector cells in response to microbial infection. Strikingly, however, the specification of Lis1-deficient long-lived memory CD8+ T lymphocytes was impaired due, in part, to an apparent failure to differentiate appropriately to IL-15. Taken together, these findings suggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes. Twit Text FOAVip The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27029586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27029586 #FOAvip English Wikipedia <ref>{{Cite pmid|27029586}}</ref> The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation #MMPMID27029586 Ngoi SM; Lopez JM; Chang JT J Immunol 2016[May]; 196 (10): 4237-45 PMID27029586show ga The microtubule-associated protein Lissencephaly 1 (Lis1) is a key regulator of cell division during stem cell renewal and differentiation. In this study, we examined the role of Lis1 in T lymphocyte homeostasis and fate diversification in response to microbial infection. T cell-specific deletion of Lis1 resulted in depletion of the peripheral CD4+ and CD8+ T lymphocyte pool, owing to a loss of homeostatic, cytokine-induced proliferation. By contrast, cognate antigen-triggered proliferation was much less affected, enabling Lis1-deficient CD8+ T cells to differentiate into terminal effector cells in response to microbial infection. Strikingly, however, the specification of Lis1-deficient long-lived memory CD8+ T lymphocytes was impaired due, in part, to an apparent failure to differentiate appropriately to IL-15. Taken together, these findings suggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes. äThe Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeost(epmc).pdf DeepDyve Pubget Overpricing