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10.4049/jimmunol.1501896 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501896 C4868629!4868629!27001958     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (9): 3537-41 Nephropedia Template TP {{tp|p=27001958|t=2016. Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression |pdf=|usr=}}{{27001958}} gab.com Text Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27001958 #FOAvip Previously we have shown that transcription factor Foxp1 plays an essential role in maintaining naive T cell quiescence; in the absence of Foxp1, mature naive CD8+ T cells proliferate in direct response to homeostatic cytokine IL-7. Here we report that the deletion of Foxp1 in naive CD8+ T cells leads to enhanced activation of PI3K/Akt/mTOR signaling pathway and its downstream cell growth and metabolism targets in response to IL-7. We found that Foxp1 directly regulates Pik3ip1, a negative regulator of PI3K. In addition, we found that deletion of Foxp1 in naive CD8+ T cells results in increased expression levels of E2fs, the critical components for cell cycle progression and proliferation, in a manner that is not associated with increased phosphorylation of retinoblastoma protein (Rb). Taken together, our studies suggest that Foxp1 enforces naive CD8+ T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression. Twit Text FOAVip Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27001958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27001958 #FOAvip English Wikipedia <ref>{{Cite pmid|27001958}}</ref> Foxp1 controls naive CD8+ T cell quiescence by simultaneously repressing key pathways in cellular metabolism and cell cycle progression #MMPMID27001958 Wei H; Geng J; Shi B; Liu Z; Wang YH; Stevens AC; Sprout SL; Yao M; Wang H; Hu H J Immunol 2016[May]; 196 (9): 3537-41 PMID27001958show ga Previously we have shown that transcription factor Foxp1 plays an essential role in maintaining naive T cell quiescence; in the absence of Foxp1, mature naive CD8+ T cells proliferate in direct response to homeostatic cytokine IL-7. Here we report that the deletion of Foxp1 in naive CD8+ T cells leads to enhanced activation of PI3K/Akt/mTOR signaling pathway and its downstream cell growth and metabolism targets in response to IL-7. We found that Foxp1 directly regulates Pik3ip1, a negative regulator of PI3K. In addition, we found that deletion of Foxp1 in naive CD8+ T cells results in increased expression levels of E2fs, the critical components for cell cycle progression and proliferation, in a manner that is not associated with increased phosphorylation of retinoblastoma protein (Rb). Taken together, our studies suggest that Foxp1 enforces naive CD8+ T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression. äFoxp1 controls naive CD8+ T cell quiescence by simultaneously repressi(epmc).pdf DeepDyve Pubget Overpricing