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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Phys+Chem+B
2010 ; 114
(48
): 15723-41
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gab.com Text
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Quantum chemical studies of nucleic acids: can we construct a bridge to the RNA
structural biology and bioinformatics communities?
#MMPMID21049899
?poner J
; ?poner JE
; Petrov AI
; Leontis NB
J Phys Chem B
2010[Dec]; 114
(48
): 15723-41
PMID21049899
show ga
In this feature article, we provide a side-by-side introduction for two research
fields: quantum chemical calculations of molecular interaction in nucleic acids
and RNA structural bioinformatics. Our main aim is to demonstrate that these
research areas, while largely separated in contemporary literature, have
substantial potential to complement each other that could significantly
contribute to our understanding of the exciting world of nucleic acids. We
identify research questions amenable to the combined application of modern ab
initio methods and bioinformatics analysis of experimental structures while also
assessing the limitations of these approaches. The ultimate aim is to attain
valuable physicochemical insights regarding the nature of the fundamental
molecular interactions and how they shape RNA structures, dynamics, function, and
evolution.