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10.1172/jci.insight.86660 http://scihub22266oqcxt.onion/10.1172/jci.insight.86660 C4868256!4868256 !27195312     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27195312 &cmd=llinks): Failed to open stream: HTTP request failed! 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Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease |pdf=|usr=}}{{27195312 }} gab.com Text Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27195312 #FOAvip Gastrointestinal graft-versus-host-disease (GI-GVHD) is a life-threatening complication occurring after allogeneic hematopoietic cell transplantation (HCT), and a blood biomarker that permits stratification of HCT patients according to their risk of developing GI-GVHD would greatly aid treatment planning. Through in-depth, large-scale proteomic profiling of presymptomatic samples, we identified a T cell population expressing both CD146, a cell adhesion molecule, and CCR5, a chemokine receptor that is upregulated as early as 14 days after transplantation in patients who develop GI-GVHD. The CD4(+)CD146(+)CCR5(+) T cell population is Th17 prone and increased by ICOS stimulation. shRNA knockdown of CD146 in T cells reduced their transmigration through endothelial cells, and maraviroc, a CCR5 inhibitor, reduced chemotaxis of the CD4(+)CD146(+)CCR5(+) T cell population toward CCL14. Mice that received CD146 shRNA-transduced human T cells did not lose weight, showed better survival, and had fewer CD4(+)CD146(+)CCR5(+) T cells and less pathogenic Th17 infiltration in the intestine, even compared with mice receiving maraviroc with control shRNA- transduced human T cells. Furthermore, the frequency of CD4(+)CD146(+)CCR5(+) Tregs was increased in GI-GVHD patients, and these cells showed increased plasticity toward Th17 upon ICOS stimulation. Our findings can be applied to early risk stratification, as well as specific preventative therapeutic strategies following HCT. Twit Text FOAVip Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27195312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27195312 #FOAvip English Wikipedia <ref>{{Cite pmid|27195312 }}</ref> Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease #MMPMID27195312 Li W ; Liu L ; Gomez A ; Zhang J ; Ramadan A ; Zhang Q ; Choi SW ; Zhang P ; Greenson JK ; Liu C ; Jiang D ; Virts E ; Kelich SL ; Chu HW ; Flynn R ; Blazar BR ; Hanenberg H ; Hanash S ; Paczesny S JCI Insight 2016[May]; 1 (6 ): ä PMID27195312 show ga Gastrointestinal graft-versus-host-disease (GI-GVHD) is a life-threatening complication occurring after allogeneic hematopoietic cell transplantation (HCT), and a blood biomarker that permits stratification of HCT patients according to their risk of developing GI-GVHD would greatly aid treatment planning. Through in-depth, large-scale proteomic profiling of presymptomatic samples, we identified a T cell population expressing both CD146, a cell adhesion molecule, and CCR5, a chemokine receptor that is upregulated as early as 14 days after transplantation in patients who develop GI-GVHD. The CD4(+)CD146(+)CCR5(+) T cell population is Th17 prone and increased by ICOS stimulation. shRNA knockdown of CD146 in T cells reduced their transmigration through endothelial cells, and maraviroc, a CCR5 inhibitor, reduced chemotaxis of the CD4(+)CD146(+)CCR5(+) T cell population toward CCL14. Mice that received CD146 shRNA-transduced human T cells did not lose weight, showed better survival, and had fewer CD4(+)CD146(+)CCR5(+) T cells and less pathogenic Th17 infiltration in the intestine, even compared with mice receiving maraviroc with control shRNA- transduced human T cells. Furthermore, the frequency of CD4(+)CD146(+)CCR5(+) Tregs was increased in GI-GVHD patients, and these cells showed increased plasticity toward Th17 upon ICOS stimulation. Our findings can be applied to early risk stratification, as well as specific preventative therapeutic strategies following HCT. äProteomics analysis reveals a Th17-prone cell population in presymptom(epmc).pdf DeepDyve Pubget Overpricing