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10.1080/07391102.2015.1055303 http://scihub22266oqcxt.onion/10.1080/07391102.2015.1055303 C4867883!4867883!26017012     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2016 ; 34 (4): 705-15 Nephropedia Template TP {{tp|p=26017012|t=2016. The systematic approach to describing conformational rearrangements in G-quadruplexes |pdf=|usr=}}{{26017012}} gab.com Text The systematic approach to describing conformational rearrangements in G-quadruplexes JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=26017012 #FOAvip Conformational changes in DNA G-quadruplex (GQ)-forming regions affect genome function and, thus, compose an interesting research topic. Computer modelling may yield insight into quadruplex folding and rearrangement, particularly molecular dynamics simulations. Here, we show that specific parameters, which are distinct from those commonly used in DNA conformational analyses, must be introduced for adequate interpretation and, most importantly, convenient visual representation of the quadruplex modelling results. We report a set of parameters that comprehensively and systematically describe GQ geometry in dynamics. The parameters include those related to quartet planarity, quadruplex twist, and quartet stacking; they are used to quantitatively characterise various types of quadruplexes and rearrangements, such as quartet distortion/disruption or deviation/bulging of a single nucleotide from the quartet plane. Our approach to describing conformational changes in quadruplexes using the new parameters is exemplified by telomeric quadruplex rearrangement, and the benefits of applying this approach to analyse other structures are discussed. Twit Text FOAVip The systematic approach to describing conformational rearrangements in G-quadruplexes ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=26017012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26017012 #FOAvip English Wikipedia <ref>{{Cite pmid|26017012}}</ref> The systematic approach to describing conformational rearrangements in G-quadruplexes #MMPMID26017012 Tsvetkov V; Pozmogova G; Varizhuk A J Biomol Struct Dyn 2016[Apr]; 34 (4): 705-15 PMID26017012show ga Conformational changes in DNA G-quadruplex (GQ)-forming regions affect genome function and, thus, compose an interesting research topic. Computer modelling may yield insight into quadruplex folding and rearrangement, particularly molecular dynamics simulations. Here, we show that specific parameters, which are distinct from those commonly used in DNA conformational analyses, must be introduced for adequate interpretation and, most importantly, convenient visual representation of the quadruplex modelling results. We report a set of parameters that comprehensively and systematically describe GQ geometry in dynamics. The parameters include those related to quartet planarity, quadruplex twist, and quartet stacking; they are used to quantitatively characterise various types of quadruplexes and rearrangements, such as quartet distortion/disruption or deviation/bulging of a single nucleotide from the quartet plane. Our approach to describing conformational changes in quadruplexes using the new parameters is exemplified by telomeric quadruplex rearrangement, and the benefits of applying this approach to analyse other structures are discussed. äThe systematic approach to describing conformational rearrangements in(epmc).pdf DeepDyve Pubget Overpricing