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10.1038/srep26046 http://scihub22266oqcxt.onion/10.1038/srep26046 C4867644!4867644!27180803     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27180803|t=2016. TGF-? Signaling Regulates Cementum Formation through Osterix Expression |pdf=|usr=}}{{27180803}} gab.com Text TGF- Signaling Regulates Cementum Formation through Osterix Expression JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27180803 #FOAvip TGF-?/BMPs have widely recognized roles in mammalian development, including in bone and tooth formation. To define the functional relevance of the autonomous requirement for TGF-? signaling in mouse tooth development, we analyzed osteocalcin-Cre mediated Tgfbr2 (OCCreTgfbr2fl/fl) conditional knockout mice, which lacks functional TGF-? receptor II (T?RII) in differentiating cementoblasts and cementocytes. Strikingly, OCCreTgfbr2fl/fl mutant mice exhibited a sharp reduction in cellular cementum mass with reduced matrix secretion and mineral apposition rates. To explore the molecular mechanisms underlying the roles of TGF-? signaling through T?RII in cementogenesis, we established a mouse cementoblast model with decreased T?RII expression using OCCM-30 cells. Interestingly, the expression of osterix (Osx), one of the major regulators of cellular cementum formation, was largely decreased in OCCM-30 cells lacking T?RII. Consequently, in those cells, functional ALP activity and the expression of genes associated with cementogenesis were reduced and the cells were partially rescued by Osx transduction. We also found that TGF-? signaling directly regulates Osx expression through a Smad-dependent pathway. These findings strongly suggest that TGF-? signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation. Twit Text FOAVip TGF- Signaling Regulates Cementum Formation through Osterix Expression ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27180803 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27180803 #FOAvip English Wikipedia <ref>{{Cite pmid|27180803}}</ref> TGF-? Signaling Regulates Cementum Formation through Osterix Expression #MMPMID27180803 Choi H; Ahn YH; Kim TH; Bae CH; Lee JC; You HK; Cho ES Sci Rep 2016[]; 6 (ä): ä PMID27180803show ga TGF-?/BMPs have widely recognized roles in mammalian development, including in bone and tooth formation. To define the functional relevance of the autonomous requirement for TGF-? signaling in mouse tooth development, we analyzed osteocalcin-Cre mediated Tgfbr2 (OCCreTgfbr2fl/fl) conditional knockout mice, which lacks functional TGF-? receptor II (T?RII) in differentiating cementoblasts and cementocytes. Strikingly, OCCreTgfbr2fl/fl mutant mice exhibited a sharp reduction in cellular cementum mass with reduced matrix secretion and mineral apposition rates. To explore the molecular mechanisms underlying the roles of TGF-? signaling through T?RII in cementogenesis, we established a mouse cementoblast model with decreased T?RII expression using OCCM-30 cells. Interestingly, the expression of osterix (Osx), one of the major regulators of cellular cementum formation, was largely decreased in OCCM-30 cells lacking T?RII. Consequently, in those cells, functional ALP activity and the expression of genes associated with cementogenesis were reduced and the cells were partially rescued by Osx transduction. We also found that TGF-? signaling directly regulates Osx expression through a Smad-dependent pathway. These findings strongly suggest that TGF-? signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation. äTGF-? Signaling Regulates Cementum Formation through Osterix Expressio(epmc).pdf DeepDyve Pubget Overpricing