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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Physiol+Regul+Integr+Comp+Physiol 2016 ; 310 (6): R476-80 Nephropedia Template TP
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Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19 #MMPMID26739651
Stein LM; Yosten GLC; Samson WK
Am J Physiol Regul Integr Comp Physiol 2016[Mar]; 310 (6): R476-80 PMID26739651show ga
Adropin, a recently described peptide hormone produced in the brain and liver, has been reported to have physiologically relevant actions on glucose homeostasis and lipogenesis, and to exert significant effect on endothelial function. We describe a central nervous system action of adropin to inhibit water drinking and identify a potential adropin receptor, the orphan G protein-coupled receptor, GPR19. Reduction in GPR19 mRNA levels in medial basal hypothalamus of male rats resulted in the loss of the inhibitory effect of adropin on water deprivation-induced thirst. The identification of a novel brain action of adropin and a candidate receptor for the peptide should extend and accelerate the study of the potential therapeutic value of adropin or its mimetics for the treatment of metabolic disorders.