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10.1146/annurev-virology-031413-085505 http://scihub22266oqcxt.onion/10.1146/annurev-virology-031413-085505 C4867093!4867093!26958719     free     free     free       Annu+Rev+Virol 2014 ; 1 (1): 147-70 Nephropedia Template TP {{tp|p=26958719|t=2014. Cytoplasmic RNA Granules and Viral Infection |pdf=|usr=}}{{26958719}} gab.com Text Cytoplasmic RNA Granules and Viral Infection JO: Annu Rev Virol http://www.kidney.de/pget.php?&tw=1&pmid=26958719 #FOAvip RNA granules are dynamic cellular structures essential for proper gene expression and homeostasis. The two principle types of cytoplasmic RNA granules are stress granules (SGs), which contain stalled translation initiation complexes, and processing bodies (P-bodies, PBs), which concentrate factors involved in mRNA degradation. RNA granules are associated with gene silencing of transcripts, thus, viruses repress RNA granule functions to favor replication. This review discusses the breadth of viral interactions with cytoplasmic RNA granules, focusing on mechanisms that modulate the functions of RNA granules and that typically promote viral replication. Currently mechanisms for virus manipulation of RNA granules can be loosely grouped into three non-exclusive categories; i) cleavage of key RNA granule factors, ii) regulation of PKR activation and iii) co-opting RNA granule factors for new roles in viral replication. Viral repression of RNA granules supports productive infection by inhibiting their gene silencing functions and counteracting their role in linking stress sensing with innate immune activation. Twit Text FOAVip Cytoplasmic RNA Granules and Viral Infection ????Annu Rev Virol http://www.kidney.de/pget.php?&tw=1&pmid=26958719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26958719 #FOAvip English Wikipedia <ref>{{Cite pmid|26958719}}</ref> Cytoplasmic RNA Granules and Viral Infection #MMPMID26958719 Tsai WC; Lloyd RE Annu Rev Virol 2014[Nov]; 1 (1): 147-70 PMID26958719show ga RNA granules are dynamic cellular structures essential for proper gene expression and homeostasis. The two principle types of cytoplasmic RNA granules are stress granules (SGs), which contain stalled translation initiation complexes, and processing bodies (P-bodies, PBs), which concentrate factors involved in mRNA degradation. RNA granules are associated with gene silencing of transcripts, thus, viruses repress RNA granule functions to favor replication. This review discusses the breadth of viral interactions with cytoplasmic RNA granules, focusing on mechanisms that modulate the functions of RNA granules and that typically promote viral replication. Currently mechanisms for virus manipulation of RNA granules can be loosely grouped into three non-exclusive categories; i) cleavage of key RNA granule factors, ii) regulation of PKR activation and iii) co-opting RNA granule factors for new roles in viral replication. Viral repression of RNA granules supports productive infection by inhibiting their gene silencing functions and counteracting their role in linking stress sensing with innate immune activation. äCytoplasmic RNA Granules and Viral Infection (epmc).pdf DeepDyve Pubget Overpricing