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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Prev+Alzheimers+Dis
2016 ; 3
(2
): 105-113
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Moderate, Regular Alcohol Consumption is Associated with Higher Cognitive
Function in Older Community-Dwelling Adults
#MMPMID27184039
Reas ET
; Laughlin GA
; Kritz-Silverstein D
; Barrett-Connor E
; McEvoy LK
J Prev Alzheimers Dis
2016[Sep]; 3
(2
): 105-113
PMID27184039
show ga
BACKGROUND: Evidence suggests that moderate alcohol consumption may protect
against cognitive decline and dementia. However, uncertainty remains over the
patterns of drinking that are most beneficial. OBJECTIVE: To examine associations
between amount and frequency of alcohol consumption with multiple domains of
cognitive function in a well-characterized cohort of older community-dwelling
adults in southern California. DESIGN: Observational, cross-sectional cohort
study. SETTING: A research visit between 1988-1992 in Rancho Bernardo,
California. PARTICIPANTS: 1624 participants of the Rancho Bernardo Study (mean
age ± SD = 73.2 ± 9.3 years). Measurements: Participants completed a
neuropsychological test battery, self-administered questionnaires on alcohol
consumption and lifestyle, and a clinical health evaluation. We classified
participants according to average amount of alcohol intake into never, former,
moderate, heavy and excessive drinkers, and according to frequency of alcohol
intake, into non-drinkers, rare, infrequent, frequent and daily drinkers. We
examined the association between alcohol intake and cognitive function,
controlling for age, sex, education, exercise, smoking, waist-hip ratio,
hypertension and self-assessed health. RESULTS: Amount and frequency of alcohol
intake were significantly associated with cognitive function, even after
controlling for potentially related health and lifestyle variables. Global and
executive function showed positive linear associations with amount and frequency
of alcohol intake, whereas visual memory showed an inverted U-shaped association
with alcohol intake, with better performance for moderate and infrequent drinkers
than for non-drinkers, excessive drinkers or daily drinkers. CONCLUSIONS: In
several cognitive domains, moderate, regular alcohol intake was associated with
better cognitive function relative to not drinking or drinking less frequently.
This suggests that beneficial cognitive effects of alcohol intake may be achieved
with low levels of drinking that are unlikely to be associated with adverse
effects in an aging population.
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