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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Clin+Nutr+Metab+Care 2016 ; 19 (3): 171-6 Nephropedia Template TP
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STAT3 signaling as a potential target to treat muscle-wasting diseases #MMPMID27023048
Sala D; Sacco A
Curr Opin Clin Nutr Metab Care 2016[May]; 19 (3): 171-6 PMID27023048show ga
Purpose of review: This review summarizes our current knowledge of the role of STAT3 signaling in skeletal muscle regeneration and the maintenance of muscle mass. Recent findings: STAT3 signaling plays a pivotal role in regulating the function of multiple cell types in skeletal muscle. This includes muscle stem cells, myofibers and macrophages. It regulates muscle stem cell function by antagonizing self-renewal. STAT3 also functions in myofibers to regulate skeletal muscle mass. This is highly relevant under pathological conditions where STAT3 activation promotes protein degradation and muscle atrophy. Transient pharmacological inhibition of STAT3 partially prevents muscle wasting. However, the mechanisms responsible for the improvement of muscle condition is not currently well understood. This is due to the complexity of the system, as STAT3 has a critical role in regulating the function of several cell types residing in skeletal muscle. Summary: Muscle wasting is associated with several human diseases such as muscle dystrophies or cancer cachexia. However, currently there are no effective treatments for this condition, and there is a critical need to identify new potential targets for the development of efficient therapeutic approaches.