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Vasohibins: new transglutaminase-like cysteine proteases possessing a
non-canonical Cys-His-Ser catalytic triad
#MMPMID26794318
Sanchez-Pulido L
; Ponting CP
Bioinformatics
2016[May]; 32
(10
): 1441-5
PMID26794318
show ga
Vasohibin-1 and Vasohibin-2 regulate angiogenesis, tumour growth and metastasis.
Their molecular functions, however, were previously unknown, in large part owing
to their perceived lack of homology to proteins of known structure and function.
To identify their functional amino acids and domains, their molecular activity
and their evolutionary history, we undertook an in-depth analysis of Vasohibin
sequences. We find that Vasohibin proteins are previously undetected members of
the transglutaminase-like cysteine protease superfamily, and all possess a
non-canonical Cys-His-Ser catalytic triad. We further propose a calcium-dependent
activation mechanism for Vasohibin proteins. These findings can now be used to
design constructs for protein structure determination and to develop enzyme
inhibitors as angiogenic regulators to treat metastasis and tumour growth.
CONTACT: luis.sanchezpulido@dpag.ox.ac.uk SUPPLEMENTARY INFORMATION:
Supplementary data are available at Bioinformatics online.
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