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10.1111/micc.12278 http://scihub22266oqcxt.onion/10.1111/micc.12278 C4866498!4866498 !27015105     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27015105 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels |pdf=|usr=}}{{27015105 }} gab.com Text Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels JO: Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=27015105 #FOAvip OBJECTIVE: S1P was found to protect the ESG by inhibiting MMP activity-dependent shedding of ESG in cultured endothelial cell studies. We aimed to further test that S1P contributes to the maintenance of normal vascular permeability by protecting the ESG in intact microvessels. METHODS: We quantified the ESG in post-capillary venules of rat mesentery and measured the vascular permeability to albumin in the presence and absence of 1 ?M S1P. We also measured permeability to albumin in the presence of MMP inhibitors and compared the measured permeability with those predicted by a transport model for the inter-endothelial cleft. RESULTS: We found that in the absence of S1P, the fluorescence intensity of the FITC-anti-HS-labeled ESG was ~10% of that in the presence of S1P, whereas the measured permeability to albumin was ~6.5-fold of that in the presence of S1P. Similar results were observed with MMP inhibition. The predictions by the mathematical model further confirmed that S1P maintains microvascular permeability by preserving ESG. CONCLUSIONS: Our results show that S1P contributes to the maintenance of normal vascular permeability by protecting the ESG in intact microvessels, consistent with parallel observation in cultured endothelial monolayers. Twit Text FOAVip Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels ????Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=27015105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27015105 #FOAvip English Wikipedia <ref>{{Cite pmid|27015105 }}</ref> Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels #MMPMID27015105 Zhang L ; Zeng M ; Fan J ; Tarbell JM ; Curry FR ; Fu BM Microcirculation 2016[May]; 23 (4 ): 301-10 PMID27015105 show ga OBJECTIVE: S1P was found to protect the ESG by inhibiting MMP activity-dependent shedding of ESG in cultured endothelial cell studies. We aimed to further test that S1P contributes to the maintenance of normal vascular permeability by protecting the ESG in intact microvessels. METHODS: We quantified the ESG in post-capillary venules of rat mesentery and measured the vascular permeability to albumin in the presence and absence of 1 ?M S1P. We also measured permeability to albumin in the presence of MMP inhibitors and compared the measured permeability with those predicted by a transport model for the inter-endothelial cleft. RESULTS: We found that in the absence of S1P, the fluorescence intensity of the FITC-anti-HS-labeled ESG was ~10% of that in the presence of S1P, whereas the measured permeability to albumin was ~6.5-fold of that in the presence of S1P. Similar results were observed with MMP inhibition. The predictions by the mathematical model further confirmed that S1P maintains microvascular permeability by preserving ESG. CONCLUSIONS: Our results show that S1P contributes to the maintenance of normal vascular permeability by protecting the ESG in intact microvessels, consistent with parallel observation in cultured endothelial monolayers. |Animals [MESH] |Capillary Permeability/*physiology [MESH] |Cells, Cultured [MESH] |Endothelium, Vascular/*physiology/ultrastructure [MESH] |Female [MESH] |Glycocalyx/*physiology [MESH] |Lysophospholipids/*physiology [MESH] |Mesentery/blood supply [MESH] |Microvessels/physiology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Pres(epmc).pdf DeepDyve Pubget Overpricing