Treatment of Res?stant Cyclophosphamide Induced Haemorrhagic Cyst?t?s: Rev?ew of
Literature and Three Case Reports
#MMPMID27190887
Ebiloglu T
; Kaya E
; Yilmaz S
; Özgür G
; Kibar Y
J Clin Diagn Res
2016[Apr]; 10
(4
): PD15-6
PMID27190887
show ga
Haemorrhagic Cystitis (HC) is defined as diffuse inflammatory bladder bleeding
due to many aetiologies. Massive HC often arises from anticancer chemotherapy or
radiotherapy for the treatment of pelvic malignancies. Phosphamides are the
anti-cancer drugs used for treating breast cancer, B-cell lymphoma, leukemia,
rheumatoid arthritis and systemic lupus erythaematosis by cross-linking strands
of DNA and preventing the cell division. They are also used in bone marrow
transplantation for prevention of Graft Versus Host Disease (GVHD). Hepatic
metabolism of phosphamide forms acrolein, and acrolein makes ulceration,
haemorrhage, edema and necrosis of the urothelium during its excretion by the
urine. Infectious causes of HC in immunocomprimesed patients are adenovirus, BK
polyoma-virus (BK), JC virus, and Cytomegalovirus (CMV). The present article
attempts to make a review of literature for the treatment of intractable HC and
report three cases with HC.