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10.1074/jbc.M116.719120 http://scihub22266oqcxt.onion/10.1074/jbc.M116.719120 C4865931!4865931!27002153     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (20): 10867-75 Nephropedia Template TP {{tp|p=27002153|t=2016. The Nuclear Receptor Rev-erb? Regulates Adipose Tissue-specific FGF21 Signaling* |pdf=|usr=}}{{27002153}} gab.com Text The Nuclear Receptor Rev-erb Regulates Adipose Tissue-specific FGF21 Signaling* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27002153 #FOAvip FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erb?, a potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erb? for Rev-erb?-binding sites identified ?Klotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erb? in white adipose tissue but not liver. Rev-erb? ablation led to the robust elevated expression of ?Klotho. Consequently, the effects of FGF21 were markedly enhanced in the white adipose tissue of mice lacking Rev-erb?. A major Rev-erb?-controlled enhancer at the Klb locus was also bound by the adipocytic transcription factor peroxisome proliferator-activated receptor (PPAR) ?, which regulates its activity in the opposite direction. These findings establish Rev-erb? as a specific modulator of FGF21 signaling in adipose tissue. Twit Text FOAVip The Nuclear Receptor Rev-erb Regulates Adipose Tissue-specific FGF21 Signaling* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27002153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27002153 #FOAvip English Wikipedia <ref>{{Cite pmid|27002153}}</ref> The Nuclear Receptor Rev-erb? Regulates Adipose Tissue-specific FGF21 Signaling* #MMPMID27002153 Jager J; Wang F; Fang B; Lim HW; Peed LC; Steger DJ; Won KJ; Kharitonenkov A; Adams AC; Lazar MA J Biol Chem 2016[May]; 291 (20): 10867-75 PMID27002153show ga FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erb?, a potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erb? for Rev-erb?-binding sites identified ?Klotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erb? in white adipose tissue but not liver. Rev-erb? ablation led to the robust elevated expression of ?Klotho. Consequently, the effects of FGF21 were markedly enhanced in the white adipose tissue of mice lacking Rev-erb?. A major Rev-erb?-controlled enhancer at the Klb locus was also bound by the adipocytic transcription factor peroxisome proliferator-activated receptor (PPAR) ?, which regulates its activity in the opposite direction. These findings establish Rev-erb? as a specific modulator of FGF21 signaling in adipose tissue. äThe Nuclear Receptor Rev-erb? Regulates Adipose Tissue-specific FGF21 (epmc).pdf DeepDyve Pubget Overpricing