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10.1038/srep25823 http://scihub22266oqcxt.onion/10.1038/srep25823 C4865869!4865869!27172998     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27172998|t=2016. The small GTPases Ras and Rap1 bind to and control TORC2 activity |pdf=|usr=}}{{27172998}} gab.com Text The small GTPases Ras and Rap1 bind to and control TORC2 activity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27172998 #FOAvip Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any system. In Dictyostelium, TORC2 functions at the front of migrating cells downstream of the Ras protein RasC, controlling F-actin dynamics and cAMP production. Here, we report the identification of the small GTPase Rap1 as a conserved binding partner of the TORC2 component RIP3/SIN1, and that Rap1 positively regulates the RasC-mediated activation of TORC2 in Dictyostelium. Moreover, we show that active RasC binds to the catalytic domain of TOR, suggesting a mechanism of TORC2 activation that is similar to Rheb activation of TOR complex 1. Dual Ras/Rap1 regulation of TORC2 may allow for integration of Ras and Rap1 signaling pathways in directed cell migration. Twit Text FOAVip The small GTPases Ras and Rap1 bind to and control TORC2 activity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27172998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27172998 #FOAvip English Wikipedia <ref>{{Cite pmid|27172998}}</ref> The small GTPases Ras and Rap1 bind to and control TORC2 activity #MMPMID27172998 Khanna A; Lotfi P; Chavan AJ; Montaņo NM; Bolourani P; Weeks G; Shen Z; Briggs SP; Pots H; Van Haastert PJM; Kortholt A; Charest PG Sci Rep 2016[]; 6 (ä): ä PMID27172998show ga Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any system. In Dictyostelium, TORC2 functions at the front of migrating cells downstream of the Ras protein RasC, controlling F-actin dynamics and cAMP production. Here, we report the identification of the small GTPase Rap1 as a conserved binding partner of the TORC2 component RIP3/SIN1, and that Rap1 positively regulates the RasC-mediated activation of TORC2 in Dictyostelium. Moreover, we show that active RasC binds to the catalytic domain of TOR, suggesting a mechanism of TORC2 activation that is similar to Rheb activation of TOR complex 1. Dual Ras/Rap1 regulation of TORC2 may allow for integration of Ras and Rap1 signaling pathways in directed cell migration. äThe small GTPases Ras and Rap1 bind to and control TORC2 activity (epmc).pdf DeepDyve Pubget Overpricing