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10.7554/eLife.12850 http://scihub22266oqcxt.onion/10.7554/eLife.12850 C4865369!4865369 !27074666     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27074666 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration |pdf=|usr=}}{{27074666 }} gab.com Text Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=27074666 #FOAvip Mechanisms enabling positional identity re-establishment are likely critical for tissue regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is known about how regeneration signaling restores regionalization along body or organ axes. We identify three genes expressed constitutively in overlapping body-wide transcriptional gradients that control trunk-tail positional identity in regeneration. ptk7 encodes a trunk-expressed kinase-dead Wnt co-receptor, wntP-2 encodes a posterior-expressed Wnt ligand, and ndl-3 encodes an anterior-expressed homolog of conserved FGFRL/nou-darake decoy receptors. ptk7 and wntP-2 maintain and allow appropriate regeneration of trunk tissue position independently of canonical Wnt signaling and with suppression of ndl-3 expression in the posterior. These results suggest that restoration of regional identity in regeneration involves the interpretation and re-establishment of axis-wide transcriptional gradients of signaling molecules. Twit Text FOAVip Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=27074666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27074666 #FOAvip English Wikipedia <ref>{{Cite pmid|27074666 }}</ref> Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration #MMPMID27074666 Lander R ; Petersen CP Elife 2016[Apr]; 5 (ä): ä PMID27074666 show ga Mechanisms enabling positional identity re-establishment are likely critical for tissue regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is known about how regeneration signaling restores regionalization along body or organ axes. We identify three genes expressed constitutively in overlapping body-wide transcriptional gradients that control trunk-tail positional identity in regeneration. ptk7 encodes a trunk-expressed kinase-dead Wnt co-receptor, wntP-2 encodes a posterior-expressed Wnt ligand, and ndl-3 encodes an anterior-expressed homolog of conserved FGFRL/nou-darake decoy receptors. ptk7 and wntP-2 maintain and allow appropriate regeneration of trunk tissue position independently of canonical Wnt signaling and with suppression of ndl-3 expression in the posterior. These results suggest that restoration of regional identity in regeneration involves the interpretation and re-establishment of axis-wide transcriptional gradients of signaling molecules. |*Gene Expression Regulation [MESH] |Animals [MESH] |Body Patterning/*genetics [MESH] |Cell Differentiation [MESH] |Helminth Proteins/*genetics/metabolism [MESH] |Planarians/*genetics/metabolism/ultrastructure [MESH] |Receptor Protein-Tyrosine Kinases/*genetics/metabolism [MESH] |Receptors, Fibroblast Growth Factor/*genetics/metabolism [MESH] |Receptors, Wnt/genetics/metabolism [MESH] |Regeneration/genetics [MESH] |Stem Cells/cytology/metabolism [MESH] |Transcription, Genetic [MESH] |Wnt Proteins/*genetics/metabolism [MESH] |Wnt Signaling Pathway [MESH]Wnt, Ptk7, and FGFRL expression gradients control trunk positional ide(epmc).pdf DeepDyve Pubget Overpricing