Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27170263
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Brain Radiation Information Data Exchange (BRIDE): integration of experimental
data from low-dose ionising radiation research for pathway discovery
#MMPMID27170263
Karapiperis C
; Kempf SJ
; Quintens R
; Azimzadeh O
; Vidal VL
; Pazzaglia S
; Bazyka D
; Mastroberardino PG
; Scouras ZG
; Tapio S
; Benotmane MA
; Ouzounis CA
BMC Bioinformatics
2016[May]; 17
(1
): 212
PMID27170263
show ga
BACKGROUND: The underlying molecular processes representing stress responses to
low-dose ionising radiation (LDIR) in mammals are just beginning to be
understood. In particular, LDIR effects on the brain and their possible
association with neurodegenerative disease are currently being explored using
omics technologies. RESULTS: We describe a light-weight approach for the storage,
analysis and distribution of relevant LDIR omics datasets. The data integration
platform, called BRIDE, contains information from the literature as well as
experimental information from transcriptomics and proteomics studies. It deploys
a hybrid, distributed solution using both local storage and cloud technology.
CONCLUSIONS: BRIDE can act as a knowledge broker for LDIR researchers, to
facilitate molecular research on the systems biology of LDIR response in mammals.
Its flexible design can capture a range of experimental information for genomics,
epigenomics, transcriptomics, and proteomics. The data collection is available
at: .
free
free
free
