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10.1186/s12872-016-0266-7

http://scihub22266oqcxt.onion/10.1186/s12872-016-0266-7
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C4865004!4865004!27169633
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suck abstract from ncbi


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pmid27169633      BMC+Cardiovasc+Disord 2016 ; 16 (ä): ä
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  • Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease #MMPMID27169633
  • Wang H; Wang R; Du D; Li F; Li Y
  • BMC Cardiovasc Disord 2016[]; 16 (ä): ä PMID27169633show ga
  • Background: Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD. Methods: CTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay. Further analysis of CTRP 1 levels in different stages and lesion vessels of CAD were conducted. Results: Serum levels of CTRP 1 in CAD patients were significantly elevated, and it was increased with the severity of CAD. CTRP 1 level in acute myocardial infarction group was much higher than that in stable/unstable angina and non-CAD groups. And significant differences of CTRP 1 were also found between single-vessel disease and triple-vessel disease. Multiple logistic regression analysis showed that CTRP 1 was an independent risk factor of the occurrence of myocardial infarction. Conclusions: Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction.
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